{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:32:26Z","timestamp":1788532346345,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on preemptive analgesia in periodontal surgeries are scarce and still diverse. The aim of this study was to evaluate and compare the analgesic effects of the preemptive administration of ibuprofen and nimesulide in open flap periodontal surgeries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present randomized controlled clinical trial comprised 40 individuals, divided into two groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a020), according to the test drug (ibuprofen and nimesulide) to be administered 1\u00a0hour preoperatively. Participants underwent bilateral periodontal surgeries at two different times, and were randomly given the test drug or placebo in a split\u2010mouth design. Postoperative pain and rescue medication were evaluated at different times. Comparisons between ibuprofen and nimesulide were performed through a Generalized Estimation Equation model, using test drug and evaluation times, along with an interaction between these two variables as predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In intergroup comparisons regarding pain control, ibuprofen showed better effects than placebo only at the first postoperative hour, whereas nimesulide showed better effects than placebo at 1, 6, 24, and 48 postoperative hours. In intergroup comparisons, nimesulide showed better effects than ibuprofen at 24, 48, and 72 postoperative hours, demonstrating a higher overall preemptive effect. No differences were observed in relation to the number of rescue medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preemptive administration of nimesulide showed better overall preemptive effects on postoperative pain control when compared with ibuprofen.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.20-0887","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T02:19:30Z","timestamp":1621909170000},"page":"300-309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Preemptive effects of ibuprofen and nimesulide on postoperative pain control after open flap periodontal surgeries: A randomized placebo\u2010controlled split\u2010mouth clinical trial"],"prefix":"10.1002","volume":"93","author":[{"given":"Bianca F. E.","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Dental Clinics, Oral Pathology, and Oral Surgery, School of Dentistry Federal University of Minas Gerais  Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7687-1238","authenticated-orcid":false,"given":"Fernando O.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Dental Clinics, Oral Pathology, and Oral Surgery, School of Dentistry Federal University of Minas Gerais  Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M. 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