{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:10:41Z","timestamp":1789495841335,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The autogenous connective tissue graft (CTG) with coronally advanced flap (CTG+CAF) is the \"gold standard\" for recession defect coverage; however, researchers continue to pursue lower morbidity, more convenient and unlimited supply harvest graft substitutes, including those that could provide soft tissue volume augmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, controlled, double\u2010masked comparison of a volume\u2010stable collagen matrix (VCMX) versus CTG was conducted at four clinical investigation sites. Single, contralateral, within patient matched\u2010pair, RT1 recession defects were treated with VCMX+CAF (test) and CTG+CAF (control). The primary efficacy end point was percent root coverage at 6 months. Secondary efficacy end points included clinical measures such as soft tissue volume, attachment level, and keratinized tissue width. Patient\u2010reported outcomes included measures such as discomfort, esthetics, and overall satisfaction; 6\u2010month end point results were followed for 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients received control and test therapies, and all patients were available for follow\u2010up measures. Average percent root coverage for CTG+CAF was 90.5% \u00b1 14.87%\u00a0versus 70.7% \u00b1 28.26% for VCMX+CAF, <jats:italic>P<\/jats:italic>\u00a0&lt;0.0001. Both therapies produced significant soft tissue volume increases (84.8 \u00b1 47.43 mm<jats:sup>3<\/jats:sup> control versus 48.90 \u00b1 35.58 mm<jats:sup>3<\/jats:sup> test, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0006). The test, harvest graft substitute produced less postoperative pain and was preferred by patients at the 6\u2010month end point. All other end point measures were not significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>VCMX+CAF root coverage was inferior to CTG+CAF but produced less morbidity and was preferred by patients. Case\/patient selection and surgical technique appear key to achieving successful results with the harvest graft alternative.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.21-0131","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T05:03:58Z","timestamp":1626843838000},"page":"333-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy of a harvest graft substitute for recession coverage and soft tissue volume augmentation: A randomized controlled trial"],"prefix":"10.1002","volume":"93","author":[{"given":"Michael K.","family":"McGuire","sequence":"first","affiliation":[{"name":"The McGuire Institute (iMc \u2013 practice\u2010based clinical research network); Private practice  Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Janakievski","sequence":"additional","affiliation":[{"name":"iMc; Private practice, Tacoma, WA; Department of Periodontics, School of Dentistry University of Washington  Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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