{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:39:18Z","timestamp":1782520758054,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This randomized, crossover trial sought to determine if a preoperative intravenous (IV) dose of dexamethasone reduces pain, swelling, and analgesic usage following periodontal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010seven patients planned for two similar periodontal flap surgeries under IV sedation were enrolled. Patients were randomized to receive either 2\u00a0mL (8\u00a0mg) dexamethasone sodium phosphate or 2\u00a0mL of IV solution (placebo) before the first surgery, and 2\u00a0mL of the other solution before the second surgery. Postoperative discomfort was managed with a standardized regimen of 600\u00a0mg ibuprofen and 325\u00a0mg acetaminophen. A smartphone application was used to record self\u2010assessed pain and swelling scores using 21\u2010point numerical (NRS\u201021) and 4\u2010point verbal (VRS\u20104) rating scales as well as the number of analgesic medications taken at 12\u2010, 24\u2010, 48\u2010, 72\u2010, 168\u2010, and 336\u2010hours following each surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IV dexamethasone was associated with a significant reduction in pain at 12, 24, 48, and 72 hours (<jats:italic>P<\/jats:italic>\u00a0&lt;0.05), and swelling at 12, 24, 48, and 168 hours (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) postoperatively when compared with placebo based on NRS\u201021 responses. VRS\u20104 data showed significant reductions in pain at 12, 72, and 168 hours and swelling at 12, 24, and 168 hours postoperatively with dexamethasone. No significant differences were found in the number of tablets of ibuprofen or acetaminophen between dexamethasone and placebo surgeries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative, intravenously administered dexamethasone reduces pain and swelling within the first postoperative week following periodontal flap surgery and should be considered a useful adjunct for perioperative management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.21-0153","type":"journal-article","created":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T09:28:36Z","timestamp":1621675716000},"page":"239-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of intravenous dexamethasone on postoperative pain and swelling following periodontal flap surgery: A randomized controlled trial of patient\u2010centered outcomes"],"prefix":"10.1002","volume":"93","author":[{"given":"Michael 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