{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:28Z","timestamp":1786978228578,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T00:00:00Z","timestamp":1631404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to explore the efficacy of Nd:YAG laser\u2010assisted periodontal therapy for management of patients with stage II\u2010IV periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who presented with residual periodontal pockets were enrolled. After non\u2010surgical periodontal therapy (NSPT), test sites received Nd:YAG laser (first entrance to pocket: 3 W, 100 \u03bcs, 20\u00a0Hz; second entrance: 4 W, 600 \u03bcs, 20\u00a0Hz) and control sites received placebo (laser off). Periodontal probing depth (PPD), clinical attachment level (CAL), gingival recession (GR), bleeding on probing (BOP), and plaque index (PI) were recorded at baseline and 1, 2, 3, 4 and 6\u2010month visits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty patients completed the 6\u2010month period. Significant reductions in PPD, CAL, BOP, and PI values and a significant increase in GR at all follow\u2010up visits compared to the baseline (all\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) were revealed in both groups. Test sites showed significantly greater improvement in PPD (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0002) and greater increase in GR (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) compared to the control sites at 6\u2010month visit. There was no difference between two groups regarding CAL gain through the study period (\n                      <jats:italic>P\u00a0=\u00a0<\/jats:italic>\n                      0.23).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NSPT+Nd:YAG laser with the current protocol results in greater PPD reduction compared to NSPT alone. However, this reduction is likely because of greater GR rather than attachment gain. Therefore, the adjunction of Nd:YAG laser (with the current setting) to the NSPT for the treatment of residual periodontal pockets did not ameliorate the clinical outcomes (ClinicalTrials.gov ID: NCT03365167).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.21-0242","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T13:45:41Z","timestamp":1629380741000},"page":"662-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of Nd:YAG laser\u2010assisted periodontal therapy for the management of periodontitis: A double\u2010blind split\u2010mouth randomized controlled clinical trial"],"prefix":"10.1002","volume":"93","author":[{"given":"Dorara","family":"Dortaj","sequence":"first","affiliation":[{"name":"Laser Research Center of Dentistry, Dentistry Research Institute Tehran University of Medical Sciences  Tehran Iran"},{"name":"Operative Department, School of Dentistry Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hossein","family":"Bassir","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Hakimiha","sequence":"additional","affiliation":[{"name":"Laser Research Center of Dentistry, Dentistry Research Institute Tehran University of Medical Sciences  Tehran Iran"},{"name":"Laser Application in Medical Sciences Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houlin","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Family, Population and Preventive Medicine Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoori","family":"Aslroosta","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Fekrazad","sequence":"additional","affiliation":[{"name":"Radiation Sciences Research Center, Laser Research Center in Medical Sciences AJA University of Medical Sciences, School of Dentistry  Tehran Iran"},{"name":"International Network for Photo Medicine and Photo Dynamic Therapy (INPMPDT) Universal Scientific Education and Research Network (USERN)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Moslemi","sequence":"additional","affiliation":[{"name":"Dental Research Center, Dentistry Research Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12297"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12156"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2020.04.014"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12137"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12123"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5037.2009.00375.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.8.701"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.160504"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2017.03.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090700"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-0939-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2011.3184"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-010-0807-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22483"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01695.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-010-0795-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2014.3793"},{"key":"e_1_2_9_22_1","first-page":"577","article-title":"Histologic evaluation of an Nd:yAG laser\u2010assisted new attachment procedure in humans","volume":"27","author":"Yukna RA","year":"2007","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_9_23_1","first-page":"497","article-title":"Human clinical and histologic evaluation of laser\u2010assisted new attachment procedure","volume":"32","author":"Nevins ML","year":"2012","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.1848"},{"key":"e_1_2_9_25_1","article-title":"Change in clinical indices following laser or scalpel treatment for periodontitis: a split\u2010mouth, randomized, multi\u2010center trial. Proc SPIE 8929","volume":"89290","author":"Harris DM","journal-title":"Lasers in Dentistry XX"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.02.005"},{"key":"e_1_2_9_27_1","first-page":"88","article-title":"Laser ENAP for periodontal bone regeneration","volume":"17","author":"Gregg RH","year":"1998","journal-title":"Dent Today"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12024"},{"key":"e_1_2_9_29_1","first-page":"57","article-title":"Clinical effectiveness of laser assisted new attachment procedure as an adjunct to nonsurgical periodontal treatment: a randomized clinical study","volume":"7","author":"Katuri KK","year":"2015","journal-title":"J Int Oral Health"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2451-7"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.77.1.111"},{"key":"e_1_2_9_32_1","first-page":"163","article-title":"Immediate effects of laser\u2010assisted new attachment procedure (LANAP) on human periodontitis microbiota","volume":"20","author":"McCawley TK","year":"2018","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.21-0242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JPER.21-0242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.21-0242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:02:57Z","timestamp":1760882577000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/JPER.21-0242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,12]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/JPER.21-0242"],"URL":"https:\/\/doi.org\/10.1002\/jper.21-0242","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,12]]},"assertion":[{"value":"2021-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}