{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:04:19Z","timestamp":1773893059859,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Refractory jaw osteonecrosis that occurs in osteoporotic or cancer patients treated with bisphosphonates is called medication\u2010related osteonecrosis of the jaw but its underlying mechanism is unclear. Statins, therapeutic agents for dyslipidemia, lower blood low\u2010density lipoprotein cholesterol. Fluvastatin promotes the healing of tooth extraction sockets and reduces the risk of developing medication\u2010related osteonecrosis of the jaw\u2010like lesions. We used a rat model to investigate whether injecting fluvastatin at extraction sites promoted the healing of medication\u2010related osteonecrosis of the jaw\u2010like lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Upper first molars of rats administered zoledronate and dexamethasone for 2\u00a0weeks were extracted. Two weeks after tooth extraction, rats with medication\u2010related osteonecrosis of the jaw\u2010like lesions (bone exposure) were included in this study. A single injection of fluvastatin was administered in the vicinity of the medication\u2010related osteonecrosis of the jaw\u2010like onset site in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distance between the edges of the epithelia, the length of the necrotic bone exposed toward the oral cavity, the area of the necrotic bone, and the necrotic bone ratio were significantly smaller in the fluvastatin\u2010administered group compared with the saline group. A single application of fluvastatin near the site of medication\u2010related osteonecrosis of the jaw onset showed a tendency to close the epithelium, reduce necrotic bone, and form new bone, even when symptoms had already developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that a single topical administration of fluvastatin may be a novel treatment for medication\u2010related osteonecrosis of the jaw.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.21-0294","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T13:32:11Z","timestamp":1631453531000},"page":"837-846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Therapeutic effect of fluvastatin on medication\u2010related osteonecrosis of the jaw"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-8204","authenticated-orcid":false,"given":"Koma","family":"Sanda","sequence":"first","affiliation":[{"name":"Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0039-716X","authenticated-orcid":false,"given":"Yasunori","family":"Ayukawa","sequence":"additional","affiliation":[{"name":"Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Yasunami","sequence":"additional","affiliation":[{"name":"Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science Kyushu University  Fukuoka 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