{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:06:11Z","timestamp":1790633171538,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the association between peri\u2010implant diseases and systemic inflammation assessed by serum C\u2010reactive protein (CRP) levels in a sample of patients with hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 151 participants with hypertension were included in a cross\u2010sectional study. The population was divided into six groups according to their peri\u2010implant and periodontal status (healthy controls, mucositis, peri\u2010implantitis, periodontitis, periodontitis and mucositis, periodontitis, and peri\u2010implantitis). Linear, logistic regression, and correlation analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CRP levels were statistically significantly higher in participants with periodontitis alone (median 3.2\u00a0mg\/L, interquartile range [IQR] 1.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012), combined with mucositis (3.10\u00a0mg\/L, IQR 2.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) or peri\u2010implantitis (2.7\u00a0mg\/L, IQR 2.53,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002) when compared to the healthy controls (1\u00a0mg\/L, IQR 1.2). This association was independent of age, sex, smoking status, and adiposity differences. Participants with periodontitis with and without peri\u2010implant diseases had the greatest odds of exhibiting CRP\u00a0&gt;\u00a03\u00a0mg\/L (odds ratio\u00a0=\u00a07.3, 95% confidence interval 1.6\u201333.9).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Peri\u2010implant diseases are associated with systemic inflammation, but the nature of the association should be further investigated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.21-0338","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T06:14:06Z","timestamp":1715667246000},"page":"525-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Peri\u2010implant diseases and systemic inflammation: A preliminary analysis from a cross\u2010sectional survey of patients with hypertension"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1173-3029","authenticated-orcid":false,"given":"Marco","family":"Orlandi","sequence":"first","affiliation":[{"name":"University College London (UCL) Eastman Dental Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Pranno","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillo\u2010Facial Sciences \"Sapienza\" University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipul","family":"Patel","sequence":"additional","affiliation":[{"name":"University College London (UCL) Eastman Dental Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2564-530X","authenticated-orcid":false,"given":"Piero","family":"Papi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillo\u2010Facial Sciences 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