{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:06:52Z","timestamp":1790633212853,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the pro\u2010inflammatory cytokine profiles in patients with or without cardiovascular disease (CVD) and with or without peri\u2010implantitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum, peri\u2010implant crevicular fluid (PICF), and gingival crevicular fluid (GCF) were collected from patients with (<jats:italic>n<\/jats:italic>\u00a0=\u00a082) or without CVD (<jats:italic>n<\/jats:italic>\u00a0=\u00a046) at the most severe peri\u2010implantitis site including sites with periodontitis. A panel of proinflammatory molecules including high\u2010sensitivity C\u2010reactive protein (hsCRP), fibrinogen, interleukin\u20101 beta (IL\u20101<jats:italic>\u03b2<\/jats:italic>), IL\u20106, plasma tumor necrosis factor\u2010alpha (TNF\u2010<jats:italic>\u03b1<\/jats:italic>), matrix metallo\u2010proteinase\u20108 (MMP\u20108), osteoprotegerin (OPG), vascular endothelial growth factor (VEGF), IL\u201017, IL\u20108, tissue inhibitor of metalloproteinase\u20102 (TIMP\u20102), myeloperoxidase (MPO), and prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) were analyzed using human custom Quantibody arrays. Krunskal\u2010Wallis test was used to compare groups. The diagnostic ability of each biomarker was assessed using chi\u2010square test and ROC analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum IL\u20101<jats:italic>\u03b2<\/jats:italic>, TNF\u2010<jats:italic>\u03b1<\/jats:italic> and fibrinogen were significantly higher in CVD patients than those without. Serum fibrinogen displayed a trend of higher concentration in patients with radiographic bone loss (RBL) \u22652\u00a0mm (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.08). PICF TNF\u2010<jats:italic>\u03b1<\/jats:italic> exhibited a significantly higher detection level in the CVD patients that is coincided with the local peri\u2010implant inflammation. In addition, PICF MMP\u20108 was significantly higher in the RBL \u22652\u00a0mm sites than the healthy implants; whereas IL\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20108, MMP\u20108, and TIMP\u20102 proved to be the significant predictors for peri\u2010implant disease. GCF TNF\u2010<jats:italic>\u03b1<\/jats:italic> collected from patients with periodontitis was significantly associated with CVD cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The augmented expression of local and systemic pro\u2010inflammatory cytokines found in the current study supports the weak association between the chronic peri\u2010implantitis with increasing severity and CVD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.21-0419","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T10:06:59Z","timestamp":1637575619000},"page":"824-836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Pro\u2010inflammatory profiles in cardiovascular disease patients with 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