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Using a mini pig model, the rate of reparative osteogenesis in two types of implant sites for example, an osteotomy versus a fresh extraction socket were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight adult mini pigs were used for the study. In phase I, three premolars were extracted on one side of the oral cavity; 12\u00a0weeks later, in phase II, osteotomies were produced in healed extraction sites, and contralateral premolars were extracted. Animals were sacrificed 1, 5, and 12\u00a0weeks after phase II. Bone repair and remodeling were evaluated using quantitative micro\u2010computed tomographic imaging, histology, and histochemical assays coupled with quantitative dynamic histomorphometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One week after surgery, extraction sockets and osteotomy sites exhibited similar patterns of new bone deposition. Five weeks after surgery, mineral apposition rates (MARs) were elevated at the injury sites relative to intact bone. Twelve weeks after surgery, the density of new bone in both injury sites was equivalent to intact bone but quantitative dynamic histomorphometry and cellular activity assays demonstrated bone remodeling was still underway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The mechanisms and rates of reparative osteogenesis were equivalent between fresh extraction sockets and osteotomies. The volume of new bone required to fill a socket, however, was significantly greater than the volume required to fill an osteotomy. These data provide a framework for estimating the rate of reparative osteogenesis and the time to loading of implants placed in healed sites versus fresh extraction sockets.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.21-0426","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:50:47Z","timestamp":1645577447000},"page":"1701-1711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multiscale analysis of craniomaxillofacial bone repair: A preclinical mini\u2010pig study"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1959-8618","authenticated-orcid":false,"given":"Pavla","family":"Ticha","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Department of Surgery Stanford University School of Medicine  Stanford California USA"},{"name":"Department of Plastic Surgery, 3rd Faculty of Medicine and University 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