{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:06:34Z","timestamp":1791986794018,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present study was to evaluate the clinical efficacy of the diode laser as an adjunct to scaling and root planing (SRP) and also determine the biochemical profile by evaluating the gingival crevicular fluid (GCF) levels of interleukin (IL)\u201017, IL\u201010, tumor necrosis factor\u2010related weak inducer of apoptosis (TWEAK), and sclerostin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 40 systemically healthy, patients with Stage III periodontitis were included in this randomized controlled study. Participants were randomly divided into two groups as SRP + diode laser (L) (0.80W power, 940\u00a0nm wavelength and 0.80J\/s energy level) and only SRP group. Recording of periodontal parameters and collecting GCF samples were performed at baseline, first and 3rd months. Biomarker levels in GCF were measured with ELISA<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, no significant difference was detected between groups in terms of both clinical and biochemical parameters. All biochemical parameters (except for IL\u201010 in control group), presented a statistically significant difference for 3 months study period in both groups. When laser and control groups were compared, significant differences were not observed, except the lower GCF IL\u201017 levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.025), bleeding on probing (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.028), and clinical attachment level (CAL) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0002) values in laser group at third, first, and third months, respectively. Statistically significant correlations were also noted between biochemical parameters and clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The GCF IL\u201017, TWEAK, and sclerostin levels may be useful for monitoring response to SRP+L therapy. However, long\u2010term studies on higher populations are needed to evaluate the effectiveness of adjunctive use of diode laser application to SRP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.21-0494","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T10:51:38Z","timestamp":1640688698000},"page":"1161-1172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of GCF IL\u201017, IL\u201010, TWEAK, and sclerostin levels after scaling and root planing and adjunctive use of diode laser application in patients with periodontitis"],"prefix":"10.1002","volume":"93","author":[{"given":"Ali Tugrul","family":"Gur","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guliz N.","family":"Guncu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah C.","family":"Akman","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli","family":"Pinar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem","family":"Karabulut","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahime M.","family":"Nohutcu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0721"},{"key":"e_1_2_7_3_1","article-title":"Systematic review and meta\u2010analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts","volume":"146","author":"Smiley CJ","year":"2015","journal-title":"J Am Dent Assoc"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2001.22250106.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12871"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12361"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.3.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2004.03676.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2220104.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2009.08.007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12137"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150212"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-03208-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1525744"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2017.4288"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2007.2233"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-03911-x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01259.x"},{"key":"e_1_2_7_19_1","article-title":"Short\u2010term effects of nonsurgical periodontal treatment with and without use of diode laser (980 nm) on serum levels of reactive oxygen metabolites and clinical periodontal parameters in patients with chronic periodontitis: a randomized controlled trial","volume":"45","author":"Balasubramaniam AS","year":"2014","journal-title":"Quintessence Int"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-009-0753-5"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","unstructured":"JiangY FengJ DuJ et\u00a0al.Clinical and Biochemical Effect of Laser as an Adjunct to Non\u2010Surgical Treatment of Chronic Periodontitis. 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