{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:04:39Z","timestamp":1789416279789,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this double\u2010masked, randomized, controlled trial was to determine if\u00a0the\u00a0local application of simvastatin\u00a0(SIM), combined with minimally invasive papilla reflection and root planing (PR\/RP), is effective in improving clinical attachment level (CAL), probing depth\u00a0(PD)\u00a0reduction, and increasing interproximal bone height (IBH)\u00a0in persistent 6\u20139\u00a0mm periodontal pockets in patients receiving periodontal maintenance therapy (PMT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty patients\u00a0with Stage III, Grade B periodontitis presenting with a 6\u20139\u00a0mm interproximal\u00a0PD with a history of bleeding on probing (BOP) were included in the study.\u00a0Experimental [PR\/RP+SIM\/methylcellulose (MCL); <jats:italic>n<\/jats:italic>\u00a0=\u00a027] and control (PR\/RP+MCL; <jats:italic>n<\/jats:italic>\u00a0=\u00a023) therapies were randomly assigned. Root surfaces were accessed via reflection of interproximal papillae, followed by RP assisted with endoscope evaluation, acid etching,\u00a0and\u00a0SIM\/MCL or MCL application.\u00a0CAL, PD, BOP, plaque presence, and IBH (using standardized vertical bitewing radiographs) were evaluated at baseline and 12 months. Measurements were compared by group and time using Chi\u2010square, Wilcoxon rank\u2010sum, and <jats:italic>t<\/jats:italic>\u2010tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both PR\/RP+SIM\/MCL\u00a0and PR\/RP+MCL, respectively, resulted in\u00a0improvements in clinical outcomes (CAL: \u20101.9 \u00b1 0.3\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001; \u20101.0 \u00b1 0.3\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.003; PD:\u00a0\u20102.3\u00a0mm \u00b1 0.3, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001; \u20101.3\u00a0mm \u00b1 0.3, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001; BOP: \u201058.7%; \u201041.7%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and\u00a0stable IBH (\u20100.2 \u00b1\u00a00.12, \u20100.4\u00a0\u00b1\u00a00.2,\u00a0<jats:italic>p<\/jats:italic>\u00a0=\u00a00.22)\u00a0from baseline to 12 months post\u2010therapy.\u00a0PR\/RP+SIM\/MCL had more improvement in CAL (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), PD (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007), and BOP (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.047).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The addition of SIM\/MCL to PR\/RP improved\u00a0CAL, PD, and BOP compared with PR\/RP alone in periodontal maintenance patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.21-0708","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T10:44:30Z","timestamp":1653648270000},"page":"1682-1690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of locally applied simvastatin on clinical attachment level and alveolar bone in periodontal maintenance patients: A randomized clinical trial"],"prefix":"10.1002","volume":"93","author":[{"given":"Amy C.","family":"Killeen","sequence":"first","affiliation":[{"name":"Department of Surgical Specialties University of Nebraska Medical Center College of Dentistry  Lincoln Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Krell","sequence":"additional","affiliation":[{"name":"Department of Surgical Specialties University of Nebraska Medical Center College of Dentistry  Lincoln Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattie","family":"Bertels","sequence":"additional","affiliation":[{"name":"Department of Surgical Specialties University of Nebraska Medical Center College of Dentistry  Lincoln Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Surgical Specialties University of Nebraska Medical Center College of Dentistry  Lincoln Nebraska 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Pharmacy  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Reinhardt","sequence":"additional","affiliation":[{"name":"Department of Surgical Specialties University of Nebraska Medical Center College of Dentistry  Lincoln Nebraska 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