{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:14:07Z","timestamp":1787613247651,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In our recent genome\u2010wide association study, we found that genetic polymorphisms in the complement factor H (CFH) gene and S100A gene region are strongly associated with serum matrix metalloproteinase 8 (MMP\u20108) concentration and the release of MMP\u20108 from neutrophils. As MMP\u20108 is centrally involved in the pathogenesis of periodontitis, we aimed to evaluate the presence of genetic polymorphisms of <jats:italic>S100A8\/A9\/A12<\/jats:italic>, <jats:italic>MMP8<\/jats:italic>, and <jats:italic>CFH<\/jats:italic> in periodontitis. In addition, we studied whether polymorphisms of these genes affect the concentrations of S100A8, S100A12, MMP\u20108, or complement activation marker in saliva.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We genotyped four single\u2010nucleotide polymorphisms (SNPs, rs1560833 in <jats:italic>S100A8\/A9\/A12<\/jats:italic>, rs11225395 in <jats:italic>MMP8<\/jats:italic>, rs800292 in <jats:italic>CFH<\/jats:italic>, and rs1061170 in <jats:italic>CFH<\/jats:italic>) and measured salivary concentrations of S100A8, S100A12, MMP\u20108, and terminal complement complex (TCC) in the Parogene cohort (n = 508). The cohort was composed of patients with an indication to coronary angiography and all underwent a clinical and radiographic oral examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>CFH<\/jats:italic> polymorphisms rs800292 and rs1061170 were associated with periodontal parameters. None of the polymorphisms showed association with salivary proteins. However, salivary concentrations of S100A8, S100A12, MMP\u20108, and TCC were strongly associated with the number of periodontal pockets and alveolar bone loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Interestingly, genetic variants of <jats:italic>CFH<\/jats:italic>, <jats:italic>MMP8<\/jats:italic>, and <jats:italic>S100A8\/A9\/A12<\/jats:italic> gene regions did not affect salivary levels of measured proteins. However, saliva levels of S100A8, S100A12, MMP\u20108, and TCC, and <jats:italic>CFH<\/jats:italic> polymorphisms were associated with clinical and radiographic signs of periodontitis. Our study further supports the observations that any dysregulation of complement may increase the risk of inflammatory disorders, such as periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.22-0005","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T11:57:47Z","timestamp":1647950267000},"page":"1626-1634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Common complement factor H polymorphisms are linked with periodontitis in elderly patients"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7576-090X","authenticated-orcid":false,"given":"Aino","family":"Salminen","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milla","family":"Pieti\u00e4inen","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Paju","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"M\u00e4ntyl\u00e4","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Eastern Finland  Kuopio Finland"},{"name":"Oral and 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