{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:59:06Z","timestamp":1768294746733,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present study was to compare repeated applications of antimicrobial photodynamic therapy (aPDT) to open flap debridement (OFD) in the treatment of residual periodontal pockets in non\u2010furcation sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010six subjects with a diagnosis of Stage III or IV Grade C periodontitis, that had been previously treated, participated in the study.\u00a0 Residual pockets were divided between two groups: (1) aPDT group: received ultrasonic periodontal debridement followed by immediate application of aPDT, and repeated on1st, 2nd, 7th, and 14th days; and (2) OFD group: treated by modified papilla preservation technique, where granulation tissue and visible calculus were removed with hand curettes and an ultrasonic device. Clinical, immunological, and microbiological parameters were evaluated before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both treatments were effective reducing clinical parameters of disease. OFD resulted in a greater mean probing pocket depths (PPD) reduction in deep pockets (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). However, aPDT resulted in a lower occurrence of gingival recession (GR), dentin hypersensitivity (DH) and analgesic intake. Reduction in <jats:italic>Porphyromonas gingivalis<\/jats:italic> was observed in both groups.\u00a0Only the OFD group had a significant reduction in <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>. aPDT group had greater increase in interleukin 10 (IL\u201010) levels and a greater reduction of interleukin 1 beta (IL\u20101\u03b2) at 14 days when compared to the OFD group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OFD was superior in reducing PPD in deep pockets compared to the aPDT. However, OFD resulted in greater GR.\u00a0 Both treatments lowered <jats:italic>P. gingivalis<\/jats:italic> levels but only OFD reduced levels of <jats:italic>A. actinomycemtemcomitans<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.22-0059","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T09:06:24Z","timestamp":1652173584000},"page":"1671-1681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Open flap debridement compared to repeated applications of photodynamic therapy in the treatment of residual pockets: A randomized clinical trial"],"prefix":"10.1002","volume":"93","author":[{"given":"Naira M. R. 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