{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:30:29Z","timestamp":1792089029720,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to evaluate the accumulation of ions in blood and organs caused by titanium (Ti) metal particles in a mandibular defect in rats, together with a description of the local reaction of oral tissues to this Ti alloy debris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty Sprague\u2010Dawley rats were randomly distributed into three groups: an experimental group with a mandibular bone defect filled with metallic debris obtained by implantoplasty; a positive control group; and a negative control group. Thirty days after surgery, the rats were euthanized and perilesional tissue surrounding the mandibular defect was removed, together with the lungs, spleen, liver, and brain. Two blood samples were collected: immediately before surgery and before euthanasia. The perilesional tissue was histologically analyzed using hematoxylin\u2010eosin staining, and Ti, aluminum, and vanadium ion concentrations in blood and organs were measured by TQ\u2010ICP\u2010MS. Descriptive and bivariate analyses of the data were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All rats with implanted metal debris showed metal particles and a bone fracture callus on the osseous defect. The metal particles were surrounded by a foreign body reaction characterized by the presence of histiocytes and multinucleated giant cells (MNGCs). The experimental group had a significant higher concentration of Ti ions in all studied organs except lung tissue (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). In addition, there were more V ions in the brain in the experimental group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although further studies are required to confirm the clinical relevance of these results, Ti metal particles in the jaw might increase the concentration of metal ions in vital organs and induce a foreign body reaction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.22-0091","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T05:54:50Z","timestamp":1654754090000},"page":"119-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0166-8876","authenticated-orcid":false,"given":"Jorge","family":"Toledano\u2010Serrabona","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Implantology, Faculty of Medicine and Health Sciences University of Barcelona  Barcelona Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9991-2226","authenticated-orcid":false,"given":"Octavi","family":"Camps\u2010Font","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implantology, Faculty of Medicine and Health Sciences University of Barcelona  Barcelona Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona 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