{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:51:06Z","timestamp":1787597466436,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This randomized controlled trial was designed to evaluate the histological wound healing and alveolar ridge dimensional changes following ridge preservation using two different xenograft\/collagen matrices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010four patients each with non\u2010molar teeth that required extraction and replacement with dental implants were enrolled. Teeth extractions were completed with minimal flap reflection and were randomized to receive ridge preservation with either 90% bovine\u2010derived xenograft granules in a 10% porcine collagen matrix (Group A) or a sponge\u2010like matrix of 80% microparticulate hydroxyapatite alloplast graft with 20% sugar cross\u2010linked porcine type 1 collagen (Group B). After 16\u00a0weeks of healing and at the time of implant placement, a bone core biopsy was harvested followed by dental implant placement. The primary histological outcome evaluated were percentage of vital bone formation and connective tissue\/other (fibrous tissue and marrow space). Secondary outcomes included the change in alveolar ridge width and the buccal and lingual ridge height. Statistical analysis was completed with two\u2010sample\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test and Fisher exact test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010four patients completed the study, 23 in group A and 21 in group B. Group B presented with statistically significantly (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.02) more percentage of vital bone (39.3\u00a0\u00b1\u00a017.8) than group A (26.8\u00a0\u00b1\u00a015.8). No statistically significant difference was observed for changes in alveolar ridge dimensions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Group B, when used for ridge preservation, yields statistically significantly more vital bone over a 4\u2010month healing period. Ridge dimension changes were similar between the two groups and were adequate for implant placement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.22-0149","type":"journal-article","created":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T08:38:35Z","timestamp":1654331915000},"page":"1691-1700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparing the histological assessment following ridge preservation using a composite bovine\u2010derived xenograft versus an alloplast hydroxyapatite\u2010sugar cross\u2010linked collagen matrix"],"prefix":"10.1002","volume":"93","author":[{"given":"Alicia","family":"Casarez\u2010Quintana","sequence":"first","affiliation":[{"name":"Department of Periodontics UT Health San Antonio School of Dentistry  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian 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