{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:28:31Z","timestamp":1782307711813,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to determine the clinical and inflammatory response patterns for individual siblings diagnosed with grade C molar\u2010incisor pattern periodontitis (C\u2010MIP) and between the related siblings within families.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010nine siblings within 28 families with moderate\u2010to\u2010severe C\u2010MIP were included. Clinical parameters were evaluated for symmetry regarding the affected type of teeth, side and\/or arch, and bone loss pattern. The protein concentrations from in vitro whole blood cultures for 14 different lipopolysaccharide\u2010stimulated inflammatory markers were correlated with the extent and severity of disease, within an individual sibling and among siblings within a family.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A similar disease pattern was observed among all siblings and within families. The most common teeth affected were first molars and incisors or first molars only within the permanent dentition and only molars within the primary dentition (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Symmetry involving molars was higher than in incisors in siblings, regardless of arch or side affected (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.020). Arc\u2010shape\/vertical bone defects were the most common (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006) and higher symmetry was found for these defects in the permanent dentition (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005). Positive correlations were found between age, clinical attachment loss, and percent affected sites with several inflammatory markers. The inflammatory responses for several inflammatory markers were correlated within and among families (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.050). Specifically, the intraclass correlation coefficient within families was highest (&gt;0.5) for interleukin (IL)\u20108, IL\u20106, and IL\u201010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Families with C\u2010MIP presented similar patterns of disease. The level of an inflammatory response to bacteria seemed to play a role in the extent and severity of this disease, exemplified by the high degree of correlation in these families.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.22-0317","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T05:55:08Z","timestamp":1668232508000},"page":"811-822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pattern of grade C molar\u2010incisor pattern periodontitis in families"],"prefix":"10.1002","volume":"94","author":[{"given":"Mostafa","family":"Tabaa","sequence":"first","affiliation":[{"name":"Division of Periodontology College of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuben","family":"Adatowovor","sequence":"additional","affiliation":[{"name":"Biostatistics, College of Public Health University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avesta","family":"Shabila","sequence":"additional","affiliation":[{"name":"Division of Orthodontics, College of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorri","family":"Morford","sequence":"additional","affiliation":[{"name":"Division of Orthodontics, College of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolph","family":"Dawson","sequence":"additional","affiliation":[{"name":"Division of Periodontology College of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dublin School of Dentistry  Dublin Ireland"},{"name":"Department of Periodontology College of Dentistry 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