{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:19:51Z","timestamp":1788574791105,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The resolution of inflammation is an active process mediated by specialized lipid mediators called lipoxins and resolvins. Periodontal ligament fibroblasts (PDLFs) play a significant role in periodontal regeneration. The purpose of the current study was to determine the impact of resolvin D1 (RvD1) on human PDLF cell wound healing and proliferation, receptor expression (G\u2010protein\u2010coupled receptor 32 [GPR32] and formyl peptide\u00a0receptor\u00a02 [ALX\/FPR2]), and cytokine expression and release.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PDLFs were stimulated with interleukin\u20101\u03b2 (IL\u20101\u03b2) (500\u00a0pg\/ml) with and without RvD1 (100\u00a0nM). RvD1 receptor expression was determined by quantitative real\u2010time polymerase chain reaction (qPCR), immunofluorescence microscopy, and fluorescence\u2010activated cell sorting. Wound closure was measured by a scratch assay, and proliferation was determined by bromodeoxyuridine incorporation. Interleukin\u20106 (IL\u20106), interleukin\u20108 (IL\u20108), monocyte chemoattractant protein\u20101, cyclooxygenase\u20102, matrix metalloproteinases\u20101, \u20102, and \u20103 (MMP\u20101, \u20102, and \u20103), tissue inhibitors of metalloproteinases\u20101 and \u20102 (TIMP\u20101 and \u20102), prostaglandin E2, and osteoprotegerin (OPG) gene expression and production were measured using qPCR and Western blotting, multiplex immunoassay, and enzyme\u2010linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PDLF expressed GPR32 and ALX\/FPR2. RvD1 reversed IL\u20101\u03b2\u2010induced inhibition of wound healing and proliferation of PDLF. IL\u20101\u03b2 also induced the production of proinflammatory cytokines and MMPs. This effect was reversed by RvD1. RvD1 reversed IL\u20101\u03b2\u2012induced inhibition of TIMP\u20101, TIMP\u20102, and OPG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The data suggested that RvD1 has a pro\u2010wound healing, proliferative, and anti\u2010inflammatory impact on the PDLF that favors periodontal regeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.22-0462","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T13:37:57Z","timestamp":1669210677000},"page":"683-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Resolvin D1 modulates periodontal ligament fibroblast function"],"prefix":"10.1002","volume":"94","author":[{"given":"Ahmed E.","family":"Zarrough","sequence":"first","affiliation":[{"name":"Missouri School of Dentistry &amp; Oral Health A.T. Still University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4395-3958","authenticated-orcid":false,"given":"Hatice","family":"Hasturk","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Research Forsyth Institute  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle N.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Research Forsyth Institute  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Van Dyke","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Research Forsyth Institute  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpdogan","family":"Kantarci","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Research Forsyth Institute  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12002"},{"key":"e_1_2_8_3_1","first-page":"1624","article-title":"Position paper: guidelines for periodontal therapy","volume":"72","author":"Greenwell H","year":"2001","journal-title":"Committee Res Sci"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00317.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514557331"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(88)90184-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690080201"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.50.247"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.02601.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1998.tb02313.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600403"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2006.06.017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023381027062"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1995.tb01249.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058258"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-06133-8"},{"key":"e_1_2_8_17_1","volume-title":"Robbins and Cotran pathologic basis of disease","author":"Kumar V"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020760"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.10.7021"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.07.076"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2009.11.004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.668760"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907342107"},{"key":"e_1_2_8_24_1","first-page":"131","article-title":"The resolvin D1 receptor GPR32 transduces inflammation resolution and atheroprotection","author":"Arnardottir H","year":"2021","journal-title":"J Clin Invest"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002743200"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74405-6"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003081200"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.8.2887"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64667-6"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2005.05.004"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.1.253"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.120388"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00242.2012"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700701"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1976.47.5.256"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.09.011"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-010-0505-8"},{"key":"e_1_2_8_38_1","first-page":"317","article-title":"Fibroblasts as sentinel cells. 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