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The main goal of this retrospective longitudinal radiographic and clinical study was to investigate whether interproximal radiographic implant thread exposure after physiological bone remodeling may be a risk factor for peri\u2010implantitis. The secondary goal was to evaluate several other potential risk indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of 4325 active dental school patients having implants placed, 165 partially edentulous adults (77 men, 88 women) aged 30\u201391 with \u22652\u00a0years of follow\u2010up upon implant restoration were included. Implants with \u22651 interproximal thread exposed (no bone\u2010to\u2010implant contact) (<jats:italic>n<\/jats:italic>\u00a0=\u00a098, 35%) constituted the test group and those without exposed threads (<jats:italic>n<\/jats:italic>\u00a0=\u00a0182, 65%) the control group. Descriptive, binary, and multivariate regression analyses were evaluated for goodness of fit. Wald tests were used to evaluate for significance set at 0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 280 implants (98 test, 182 control), 8 (2.9%) failed over a mean follow\u2010up period of 7.67 (\u00b12.63) years, and 27 implants (19 test, 8 control) developed peri\u2010implantitis, with the exposed group having eight\u2010fold (7.82 times) adjusted greater odds than the non\u2010exposed. The risk increased four\u2010fold (3.77 times) with each thread exposed. No other patient\u2010 or implant\u2010related potentially confounding risk factors were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Exposed interproximal implant threads after physiologic bone remodeling may be an independent risk indicator for incident peri\u2010implantitis. Hence, clinicians should closely monitor patients with implant threads that have no bone\u2010to\u2010implant contact for incident peri\u2010implantitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.22-0499","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T06:29:15Z","timestamp":1672208955000},"page":"751-764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Interproximal implant thread exposure after initial bone remodeling as a risk indicator for peri\u2010implantitis"],"prefix":"10.1002","volume":"94","author":[{"given":"Andrea","family":"Ravid\u00e0","sequence":"first","affiliation":[{"name":"Department of Periodontics and Preventive Dentistry University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"},{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Samal","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Preventive Dentistry University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa","family":"Qazi","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Preventive Dentistry University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana Preto","family":"Webber","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Preventive Dentistry University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Preventive Dentistry University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Galindo\u2010Moreno","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implantology University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenche S.","family":"Borgnakke","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Preventive Dentistry University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad H. 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