{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:28:49Z","timestamp":1778783329401,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to compare a connective tissue graft (CTG) to a (porcine) xenogeneic acellular dermal matrix (XDM), both associated with modified coronally advanced flap (MCAF) and partial resin composite restoration to treat multiple combined defects (CDs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010eight defects in 38 patients presenting multiple combined defects, that is, gingival recession associated with non\u2010carious cervical lesions, were treated by partial resin composite restoration (apical margin up to 1\u00a0mm of the estimated cement\u2010enamel junction) and MCAF along with CTG or XDM. After 6 months, the groups were compared with regard to clinical, patient\u2010centered, and esthetic outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CD coverage was 72.9% for CTG versus 50.7% for XDM (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Recession reduction was 2.3\u00a0mm for CTG versus 1.5\u00a0mm for XDM (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). CTG resulted in a greater increase in keratinized tissue width (CTG: 0.96\u00a0mm vs. XDM: 0.3\u00a0mm,\u00a0<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) and gingival thickness (CTG: 0.9\u00a0mm vs. XDM: 0.3\u00a0mm,\u00a0<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Both treatments successfully reduced dentin hypersensitivity and increased esthetics satisfaction, with no statistically significant intergroup differences. Moreover, XDM patients experienced a shorter surgery duration (CTG: 57.2 min vs. XDM: 37.4 min,\u00a0<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and less time to no pain (visual analog scale \u00a0=\u00a0 0; CTG: 6.5 days vs. XDM: 3.5 days,\u00a0<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CTG resulted in significantly greater root coverage and increased keratinized tissue width compared to XDM for treating multiple partially restored CDs. However, increased root coverage at the CTG sites was accounted for by increased probing depth compared to the XDM sites<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.22-0516","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T02:10:15Z","timestamp":1673575815000},"page":"731-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Multiple gingival recessions associated with non\u2010carious cervical lesions treated by partial restoration and modified coronally advanced flap with either connective tissue graft or xenogeneic acellular dermal matrix: A randomized clinical trial"],"prefix":"10.1002","volume":"94","author":[{"given":"Mauro Pedrine","family":"Santamaria","sequence":"first","affiliation":[{"name":"S\u00e3o Paulo State University (Unesp). Division of Periodontics Institute of Science and Technology S\u00e3o Jos\u00e9 dos Campos  S\u00e3o Paulo Brazil"},{"name":"University of Kentucky College of Dentistry, Lexington  Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Rossato","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (Unesp). Division of Periodontics Institute of Science and Technology S\u00e3o Jos\u00e9 dos Campos  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"La\u00eds","family":"Fernanda Ferreira Ferraz","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (Unesp). Division of Periodontics Institute of Science and Technology S\u00e3o Jos\u00e9 dos Campos  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Maria Viana Miguel","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (Unesp). Division of Periodontics Institute of Science and Technology S\u00e3o Jos\u00e9 dos Campos  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Venturoso Sim\u00f5es","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (Unesp). Division of Periodontics Institute of Science and Technology S\u00e3o Jos\u00e9 dos Campos  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Pereira Nunes","sequence":"additional","affiliation":[{"name":"Proimperio Institute, S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Bresciani","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (Unesp). Division of Periodontics Institute of Science and Technology S\u00e3o Jos\u00e9 dos Campos  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"de Sanctis","sequence":"additional","affiliation":[{"name":"Departament of Periodontology Universit\u00e0 Vita\u2010Salute San Raffaele  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid Fernandes","family":"Mathias\u2010Santamaria","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (Unesp). Division of Periodontics Institute of Science and Technology S\u00e3o Jos\u00e9 dos Campos  S\u00e3o Paulo Brazil"},{"name":"Division of Operative Dentistry Department of General Dentistry University of Maryland School of Dentistry  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.10.1377"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090631"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060402"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090366"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110080"},{"issue":"2","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.1590\/1807-3107bor-2021.vol35.0096","article-title":"Rethinking the decision\u2010making process to treat 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