{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:20:10Z","timestamp":1776979210549,"version":"3.51.4"},"reference-count":68,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study evaluated the systemic (intestine and adipose tissue) and local (periodontal tissues) impact of probiotic therapy in rats with metabolic syndrome (MS) associated or not with periodontitis (PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010eight rats received a high\u2010fat diet for induction of MS for 16\u00a0weeks. They were subdivided into groups with (+) and without (\u2212) PE, receiving (*) or not (**) receiving probiotics (PROB): MS (\u2212**), MSP (\u2212*), MSPE (+**), and MSPEP (+*). PROB administration (<jats:italic>Bifidobacterium animalis<\/jats:italic> subsp. <jats:italic>lactis<\/jats:italic> HN019) started on the 8th week of the study and PE was induced on the 14th week by placing ligature on the animals\u2019 lower first molars. Euthanasia occurred in the 16th week. Biomolecular, immunoenzymatic assays, and histomorphometric analyses were performed. The data obtained were statistically analyzed (ANOVA, Tukey, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MSPEP group exhibited reduced alveolar bone loss when compared with the MSPE group, as well as lower levels of hepatic steatosis and proteinuria (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). In the intestinal environment, the MSPE group exhibited significantly\u00a0lower villus height and crypt depth, as well as a greater increase in Bacillota when compared with the MSPEP group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The MSPEP group showed lower adipokine gene expression (LEPR, NAMPT, and FABP4) in adipose tissue than the MSPE group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The probiotic <jats:italic>B. lactis<\/jats:italic> HN019 reduced the severity of experimental periodontitis and modulated the expression of lipogenic genes and intestinal morphological and microbiological parameters in rats with MS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.22-0721","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T03:27:16Z","timestamp":1681442836000},"page":"1363-1375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of probiotics in rats with experimental metabolic syndrome and periodontitis: An investigation of the intestine\u2013adipose tissue axis"],"prefix":"10.1002","volume":"94","author":[{"given":"Andr\u00e9 L. G.","family":"Moreira","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology School of Dentistry of Ribeir\u00e3o Preto University of S\u00e3o Paulo \u2013 USP  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7583-7046","authenticated-orcid":false,"given":"Pedro H. 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