{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:31:23Z","timestamp":1790361083415,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periodontitis affects systemic disease risk, although the relationship thereof in the context of different C\u2010reactive protein (CRP) levels is not clear. This study investigated the association of periodontitis with systemic diseases according to high\u2010sensitivity CRP (hs\u2010CRP) level and sought to identify the risk of systemic diseases in patients with periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from the seventh (2016\u20132018) Korea National Health and Nutrition Examination Survey. In a total of 16,489 subjects, the hs\u2010CRP group was classified into the hs\u2010CRP low\u2010risk group and the hs\u2010CRP high\u2010risk group. Propensity score matching (PSM) is used for 1:1 matching of confounding variables (e.g., age, gender, income, and education) between hs\u2010CRP low\u2010risk and hs\u2010CRP at\u2010risk groups to analyze the final 5316 subjects. The association between general characteristics and prevalence of systemic diseases was analyzed using descriptive statistics and the chi\u2010squared test. The associations between hs\u2010CRP level and systemic and periodontitis were analyzed using logistic regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within the hs\u2010CRP group, the presence of periodontitis was associated with a significantly increased prevalence of hypertension, diabetes mellitus, and stroke. In the hs\u2010CRP risk group, periodontitis significantly increased the risk of hypertension and diabetes mellitus by 2.1 and 2.4 times, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of periodontitis significantly increases the prevalence of systemic diseases and more so in individuals with higher hs\u2010CRP levels. This indicates the significance of maintaining oral health in reducing the risk of systemic diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.23-0008","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T08:24:15Z","timestamp":1697444655000},"page":"494-501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Relationship between C\u2010reactive protein level and periodontitis and systemic diseases"],"prefix":"10.1002","volume":"95","author":[{"given":"Jung\u2010Hwa","family":"Lee","sequence":"first","affiliation":[{"name":"Graduate School of Dental Hygiene Yonsei University  Seodaemun\u2010gu Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u2010Jung","family":"Mun","sequence":"additional","affiliation":[{"name":"Department of Dental Hygiene College of Software and Digital Healthcare Convergence Yonsei University  Seodaemun\u2010gu Seoul 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