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Periodontal parameters, including probing pocket depth, gingival recession, bleeding on probing, approximal plaque index, and papillary bleeding index, were assessed. Clinical attachment loss, periodontal inflamed surface area, periodontal epithelial surface area, and percentages of pocket sites with \u22643, \u22644, \u22655, \u22656, \u22657, and \u22654\u00a0mm with bleeding on probing were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All clinical parameters significantly improved from baseline to reevaluation within each group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Multinutrient intake resulted in a significantly higher reduction of probing\u2010pocket\u2010depth (\u22120.75\u00a0\u00b1\u00a00.42\u00a0mm) and bleeding\u2010on\u2010probing (\u221221.9\u00a0\u00b1\u00a016.1%) from baseline to reevaluation compared with placebo (\u22120.51\u00a0\u00b1\u00a00.30\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.040 and \u221212.5\u00a0\u00b1\u00a09.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.046, respectively). All periodontal parameters showed insignificantly higher improvements in patients receiving the supplement compared with those receiving the placebo (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Multinutrient supplementation as an adjunct to nonsurgical treatment of periodontitis showed some additional benefit regarding probing\u2010pocket\u2010depth and bleeding\u2010on\u2010probing. 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