{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:36:09Z","timestamp":1782603369060,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.310463\/2018\u201000"],"award-info":[{"award-number":["88887.310463\/2018\u201000"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate the effect of active oxygen\u2010releasing gel as an adjuvant, with and without antimicrobial photodynamic therapy (aPDT), in the treatment of residual pockets in periodontal patients with type 2 diabetes mellitus (DM2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with residual pockets with probing depth (PD) \u22654\u00a0mm and bleeding on probing (BOP) were divided into the following groups: SI (<jats:italic>n<\/jats:italic> = 17)\u2014subgingival instrumentation in a single session; BM (<jats:italic>n<\/jats:italic>\u00a0=\u00a017)\u2014SI followed by local application of active oxygen\u2010releasing gel inside the periodontal pocket for 3\u00a0min; BM\u00a0+\u00a0aPDT (<jats:italic>n<\/jats:italic>\u00a0=\u00a017)\u2014SI followed by application of BM for 3\u00a0min and pocket irrigation with methylene blue, and 660\u2010nm diode laser irradiation at 100\u00a0mW for 50\u00a0s. The periodontal clinical parameters, serum levels of glycated hemoglobin, and immunological analysis of crevicular fluid were evaluated. All data were submitted to statistical analysis (\u03b1\u00a0=\u00a05%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant reduction in BOP was verified at 90 and 180\u00a0days in the BM\u00a0+\u00a0aPDT group. The percentage of sites with PD\u00a0\u2265\u00a04\u00a0mm was significantly reduced at 90\u00a0days in BM\u00a0+\u00a0aPDT and BM, whereas after 180\u00a0days only BM showed a significant reduction. In the BM\u00a0+\u00a0aPDT group, there was a significant reduction in tumor necrosis factor \u03b1 levels at 90\u00a0days. There were no differences between the treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of adjuvant active oxygen\u2010releasing gel, with or without aPDT, resulted in the same clinical benefits as SI in the treatment of residual pockets in poorly controlled DM2 patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.23-0125","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T06:12:23Z","timestamp":1702966343000},"page":"360-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of active oxygen\u2010releasing gel and photodynamic therapy in the treatment of residual periodontal pockets in type 2 diabetic patients: A randomized controlled clinical study"],"prefix":"10.1002","volume":"95","author":[{"given":"Marina M.","family":"Cl\u00e1udio","sequence":"first","affiliation":[{"name":"Department of Diagnostics and Surgery, Periodontics Division, S\u00e3o Paulo State University (UNESP) School of Dentistry  Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir G.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Latin American Institute of Dental Research and Teaching (ILAPEO)  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubens M.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Latin American Institute of Dental Research and Teaching (ILAPEO)  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Victor S.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Surgery, Periodontics Division, S\u00e3o Paulo State University (UNESP) School of Dentistry  Ara\u00e7atuba SP Brazil"},{"name":"Center for Dental Assistance to Persons with Disabilities (CAOE) School of Dentistry  Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Wainwright","sequence":"additional","affiliation":[{"name":"Department of Biology Edge Hill University  Ormskirk Lancashire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato C. 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