{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T23:25:27Z","timestamp":1788650727176,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010613","name":"Taipei Medical University Hospital","doi-asserted-by":"publisher","award":["111TMUH\u2010MOST\u201007"],"award-info":[{"award-number":["111TMUH\u2010MOST\u201007"]}],"id":[{"id":"10.13039\/501100010613","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 111\u20102410\u2010H\u2010038\u2010020"],"award-info":[{"award-number":["MOST 111\u20102410\u2010H\u2010038\u2010020"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The lipid\u2010lowering and anti\u2010inflammatory effects of statins and fibrates may ameliorate periodontitis. Patients with hyperlipidemia tend to have a worse periodontal status. This study assessed the association between the use of statins\/fibrates and the incidence of chronic periodontitis in patients with hyperlipidemia in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study enrolled patients newly diagnosed with hyperlipidemia between 2001 and 2012 from the 2000 Longitudinal Generation Tracking Database and followed them for 5 years. The study population was divided into four groups: statin monotherapy, fibrate monotherapy, combination therapy (both statins and fibrates), and control (neither statins nor fibrates). Each patient in the treatment group was matched at a ratio of 1:1 with a control. Chronic periodontitis risk was compared in the three study arms by using a Cox proportional hazard model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic periodontitis risk was reduced by 25.7% in the combination therapy group compared with the control group (adjusted hazard ratio [aHR], 0.743; 95% confidence interval (CI), 0.678\u20130.815). Low dose (&lt;360 cumulative defined daily dose [cDDD]) and shorter duration (&lt;2 years) of statin monotherapy seem to be associated with an increased risk of chronic periodontitis; high dose (\u2265720 cDDD\/\u22651080 cDDD) and longer duration (\u22653 years) of statin\/fibrate monotherapy may be correlated with a lower risk of periodontitis. Hydrophobic statin users had a lower chronic periodontitis risk than hydrophilic statin users.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chronic periodontitis risk was lower in patients with hyperlipidemia on combination treatment with statins and fibrates, and the risk decreased when patients used statins or fibrates for &gt;3 years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.23-0166","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T15:14:25Z","timestamp":1696432465000},"page":"483-493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between antihyperlipidemic agents and the risk of chronic periodontitis in patients with hyperlipidemia: A population\u2010based retrospective cohort study in Taiwan"],"prefix":"10.1002","volume":"95","author":[{"given":"An\u2010Yi","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy, College of Pharmacy Taipei Medical University  Taipei Taiwan"},{"name":"Department of Pharmacy Linkou Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan\u2010Ling","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmacy, College of Pharmacy Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Jordan","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western Michigan University Homer Stryker M.D. School of Medicine  Kalamazoo Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Hsuan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, College of Pharmacy Taipei Medical University  Taipei Taiwan"},{"name":"Department of Pharmacy Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.38"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13506"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12331"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12630"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19124058"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1621-2"},{"key":"e_1_2_8_8_1","article-title":"C\u2010reactive protein, and periodontitis: HMG\u2010CoA\u2010reductase inhibitors (statins) as effect modifiers","volume":"2011","author":"Meisel P","year":"2011","journal-title":"ISRN Dent"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2016.11.013"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2001.tb00172.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0094-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2019-0140"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00064"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6367402"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-019-0789-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01619.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-8-16"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110756"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.130652"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12545"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160366"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-09540-y"},{"key":"e_1_2_8_23_1","unstructured":"Ministry of Health and Welfare Department of Statistics.The 2000 Longitudinal Generation Tracking Database. 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