{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:28Z","timestamp":1786978228443,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to determine the effects of smoking on early (\u22643 months) clinical outcomes and relevant molecular biomarkers following root coverage surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighteen smokers and 18 nonsmokers, status biochemically verified, with RT1 gingival recession defects were recruited and completed study procedures. All patients received coronally advanced flap plus connective tissue graft. Baseline and 3 month recession depth (RD), recession width (RW), keratinized tissue width (KTW), clinical attachment level (CAL), and gingival phenotype (GP) were recorded. Root coverage (RC) percentage and complete root coverage (CRC) were calculated. Recipient (gingival crevicular fluid) and donor (wound fluid) site VEGF\u2010A, HIF\u20101\u03b1, 8\u2010OHdG, and ANG levels were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no significant intergroup differences for any baseline or postoperative clinical parameters (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&gt;\u00a00.05), except for whole mouth gingival index (increased in nonsmokers at 3 months;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Compared to baseline, RD, RW, CAL, KTW, and GP significantly improved postoperatively, without significant intergroup differences. There were no significant intergroup differences for RC (smokers\u00a0=\u00a083%, nonsmokers\u00a0=\u00a091%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.069), CRC (smokers\u00a0=\u00a050%, nonsmokers\u00a0=\u00a072%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.177), and CAL gain (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.193). The four biomarker levels significantly increased postoperatively (day 7;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0\u2264\u00a00.042) in both groups and returned to baseline (day 28) without significant intergroup differences (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&gt;\u00a00.05). Similarly, donor site parameters were not different between groups. Strong correlations, consistent over time, were found between biomarkers implicated in angiogenesis (VEGF\u2010A, HIF\u20101\u03b1, and ANG).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The early (3 month) clinical and molecular changes after root coverage surgery utilizing a coronally advanced flap plus connective tissue graft are similar between smokers and nonsmokers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.23-0214","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T11:10:46Z","timestamp":1689160246000},"page":"17-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The effect of smoking on clinical and biochemical early healing outcomes of coronally advanced flap with connective tissue graft: Prospective cohort study"],"prefix":"10.1002","volume":"95","author":[{"given":"Duygu","family":"Ta\u015f","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara University Ankara Turkey"},{"name":"Graduate School of Health Sciences Ankara University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eivge","family":"Kurgan","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeliha","family":"G\u00fcney","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara Medipol University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhittin A.","family":"Serdar","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry School of Medicine Ac\u0131badem University Ankara 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