{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:25:46Z","timestamp":1790922346726,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T00:00:00Z","timestamp":1702080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Using a single\u2010blind, randomized, controlled, multicenter, practice\u2010based clinical trial, a volume\u2010stable collagen matrix (VCMX) was compared with connective tissue graft (CTG) for soft tissue augmentation around existing dental implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty patients (31 VCMX and 31 CTG) were included. The primary outcome was a soft tissue thickness change 3\u00a0mm below the gingival margin (GM). Secondary outcomes included clinical measures, such as keratinized tissue widths (KTw), probing pocket depths, and pink esthetic scores, and patient\u2010reported outcomes (PRO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences between test and control patient demographics or clinical measures throughout the 1\u2010year study. VCMX \u201cgrafts\u201d were by design larger than CTG, and surgery time was less (27% less, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0005). Three millimeters below the GM (primary endpoint), tissue thickness increase was noninferior for VCMX compared with CTG (0.93\u00a0\u00b1\u00a00.80\u00a0mm vs. 1.10\u00a0\u00b1\u00a00.51\u00a0mm, respectively), inferior (by 0.25\u00a0mm) at 1\u00a0mm, and noninferior at 5\u00a0mm. Postoperative pain was significantly less for VCMX patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), but all other PRO measures, including esthetics and satisfaction, improved similarly for both therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Given the inclusion criteria for this study, namely soft tissue augmentation around existing implants with some evidence of KTw and minimal recession, VCMX provided soft tissue thickness and volume increases similar (noninferior) to CTG. Clinical measures and PRO were similar between therapies\u2014site sensitivity and esthetics improved similarly for both therapies\u2014but surgery time and pain following surgery were significantly less for VCMX.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.23-0305","type":"journal-article","created":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T02:43:46Z","timestamp":1702176226000},"page":"740-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Harvest graft substitute for soft tissue volume augmentation around existing implants: A randomized, controlled and blinded multicenter trial"],"prefix":"10.1002","volume":"95","author":[{"given":"Donald S.","family":"Clem","sequence":"first","affiliation":[{"name":"The McGuire Institute (iMc \u2013 practice\u2010based clinical research network) Houston  Houston Texas USA"},{"name":"University of Texas Health Science Center San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela K.","family":"McClain","sequence":"additional","affiliation":[{"name":"The McGuire Institute (iMc \u2013 practice\u2010based clinical research network) Houston  Houston Texas USA"},{"name":"Private Practice Aurora  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"McGuire","sequence":"additional","affiliation":[{"name":"The McGuire Institute (iMc \u2013 practice\u2010based clinical research network) Houston  Houston Texas USA"},{"name":"Private Practice Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris R.","family":"Richardson","sequence":"additional","affiliation":[{"name":"The McGuire Institute (iMc \u2013 practice\u2010based clinical research network) Houston  Houston Texas USA"},{"name":"Private Practice Richmond  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg A.","family":"Santarelli","sequence":"additional","affiliation":[{"name":"The McGuire Institute (iMc \u2013 practice\u2010based clinical research network) Houston  Houston Texas USA"},{"name":"Private Practice Kenosha  Kenosha Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Schallhorn","sequence":"additional","affiliation":[{"name":"The McGuire Institute (iMc \u2013 practice\u2010based clinical research network) Houston  Houston Texas USA"},{"name":"Private Practice Aurora  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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