{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:47:53Z","timestamp":1790912873948,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study was designed to assess the influence of non\u2010surgical periodontal therapy (NSPT) on gingival crevicular fluid (GCF) levels of semaphorin\u20104D (SEMA\u20104D), peptidylarginine deiminase\u20102 (PAD\u20102), and matrix metalloproteinase\u20108 (MMP\u20108) levels in periodontally healthy, Stage III periodontitis non\u2010smoker and smoker patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty patients were equally divided into three groups, Group I: Periodontally healthy, Group II: Non\u2010smokers with Stage III periodontitis, and Group III: Smokers with Stage III periodontitis. The patients underwent NSPT with clinical and biochemical parameters examined at baseline and 3 months post therapy. GCF was collected for levels of SEMA\u20104D, PAD\u20102, and MMP\u20108 through enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Greater values of PPD (8.06\u00a0\u00b1\u00a00.19\u00a0mm), CAL (8.94\u00a0\u00b1\u00a00.19\u00a0mm), PI (2.58\u00a0\u00b1\u00a00.19) while lower PBI (1.39\u00a0\u00b1\u00a00.19%) and GI (1.72\u00a0\u00b1\u00a00.19) scores were seen in Group III as compared to Group II, which reduced significantly from baseline to 3 months in both the groups after NSPT. Minimum values of SEMA\u20104D, PAD\u20102, and MMP\u20108 levels in GCF were seen for Group I, which increased incrementally to Group II and III. Also, among Group II and III the SEMA\u20104D, PAD\u20102, and MMP\u20108 levels in GCF reduced from baseline to 3 months indicating a favorable response within the tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Greater levels in GCF of Levels of SEMA\u20104D, PAD\u20102, and MMP\u20108 in Group II and III, which reduced significantly post NSPT, implied that these biomarkers play a pivotal role in the inflammatory process and can be utilized for early diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.23-0324","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T06:34:40Z","timestamp":1697524480000},"page":"563-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative evaluation of semaphorin\u20104D, peptidylarginine deiminase\u20102, and matrix metalloproteinase\u20108 levels of gingival crevicular fluid in periodontally healthy and Stage III periodontitis smoker and non\u2010smoker patients before and after non\u2010surgical periodontal therapy"],"prefix":"10.1002","volume":"95","author":[{"given":"Aishwarya S.","family":"Ikhar","sequence":"first","affiliation":[{"name":"Department of Periodontology and Implant Dentistry VSPM Dental College and Research Centre  Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6386-1671","authenticated-orcid":false,"given":"Rajashri A.","family":"Kolte","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implant Dentistry VSPM Dental College and Research Centre  Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-5908","authenticated-orcid":false,"given":"Abhay P.","family":"Kolte","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implant Dentistry VSPM Dental College and Research Centre  Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi R.","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implant Dentistry VSPM Dental College and Research Centre  Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-0966","authenticated-orcid":false,"given":"Dhanashree G.","family":"Ghoderao","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implant Dentistry VSPM Dental College and Research Centre  Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul N.","family":"Dahake","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery VSPM Dental College and 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