{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:05:48Z","timestamp":1790024748650,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diabetes mellitus (DM)\u2010associated hyperinflammatory host response significantly provokes periodontal tissue destruction. In this context, the support of nonsurgical periodontal therapy in diabetics with host modulation agents is a current field of study. This clinical study aims to investigate the clinical efficacy of melatonin supplementation and discuss its possible biological mechanisms in nonsurgical periodontal treatment in patients with DM and periodontitis through some fundamental markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this randomized controlled and single\u2010blind study, 27 of 55 diabetic patients with periodontitis (stage III\/IV and grade C) underwent full\u2010mouth scaling and root planing (fmSRP) alone and 28 patients underwent melatonin administration (6\u00a0mg daily, 30\u00a0days) in addition to fmSRP (full\u2010mouth scaling and root planing plus melatonin, fmSRP\u2010mel). The potential therapeutic contribution of melatonin was evaluated clinically and biochemically (gingival crevicular fluid RANKL, OPG, MMP\u20108, and serum IL\u20101\u03b2 levels) at 3rd and 6th months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Melatonin (tablet, 6\u00a0mg daily, 30\u00a0days) did not cause any local or systemic side effects. fmSRP alone resulted in significant reduction in serum IL\u20101\u03b2 levels, pocket depths, gingival inflammation, and gingival crevicular fluid RANKL and MMP\u20108 levels (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Moreover, melatonin supplementation resulted in a more significant decrease in bleeding and pocket depth scores at probing, especially at 3\u00a0months (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Furthermore, RANKL and MMP\u20108 levels were significantly lower at 3\u00a0months and IL\u20101\u03b2 levels at 6\u00a0months compared to the control group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). However, OPG levels were not affected significantly by the treatments (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Melatonin, as a host modulation agent, significantly increases the clinical efficacy of fmSRP. The reduction in periodontal inflammation and pocket depths may be a result of marked suppression of RANKL\u2010associated osteoclastogenesis and extracellular matrix damage by melatonin.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.23-0335","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T21:21:30Z","timestamp":1701897690000},"page":"832-841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Melatonin supports nonsurgical periodontal treatment in patients with Type 2 diabetes mellitus and periodontitis: A randomized clinical trial"],"prefix":"10.1002","volume":"95","author":[{"given":"Yagmur","family":"Sarac Gul","sequence":"first","affiliation":[{"name":"School of Dentistry Department of Periodontology Recep Tayyip Erdogan University  Rize 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