{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:05:01Z","timestamp":1793257501024,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral care regimens can be explored to improve oral health in patients with gingivitis. This study aimed to evaluate the efficacy of a multicomponent oral care regimen with a dual zinc plus arginine (DZA) toothpaste and cetylpyridinium chloride with zinc lactate (CPC\u00a0+\u00a0Zn) mouthwash in reducing gingival bleeding in patients with gingivitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized clinical trial included 94 participants with gingivitis who were randomized into two groups: the DZA\/CPC\u00a0+\u00a0Zn group, which used a 1450\u2010ppm fluoride toothpaste containing 0.96% zinc plus 1.5% arginine and a fluoride\u2010containing mouthwash with 0.075% CPC and 0.28% zinc lactate, and the control group, which used a 1450\u2010ppm fluoride toothpaste and a placebo mouthwash for 6\u00a0months. All participants were examined by a blinded examiner who measured the gingival index, plaque index, and gingival severity index. Data were analyzed using paired <jats:italic>t<\/jats:italic> test, independent <jats:italic>t<\/jats:italic> test, and analysis of covariance (ANCOVA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups presented statistically significant reductions in all clinical parameters compared to baseline. The DZA\/CPC\u00a0+\u00a0Zn group exhibited significantly greater reductions in gingival index, gingival severity index, proximal gingival index, plaque index and proximal plaque index compared to the control group at 1, 3, and 6\u00a0months. Furthermore, DZA\/CPC\u00a0+\u00a0Zn significantly decreased the percentage of patients with generalized gingivitis over a 6\u2010month follow\u2010up period. However, differences between the DZA\/CPC\u00a0+\u00a0Zn and the control groups were not maintained after both groups established similar regimens with fluoride toothpaste.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The multicomponent oral care regimen consisting of DZA toothpaste and CPC\u00a0+\u00a0Zn mouthwash is effective in reducing gingival inflammation and supragingival biofilm in patients with gingivitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.23-0361","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:25:36Z","timestamp":1696519536000},"page":"350-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effect of a multicomponent oral care regimen on gingival inflammation: A randomized controlled clinical trial"],"prefix":"10.1002","volume":"95","author":[{"given":"Guilherme C. L. 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