{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:59:08Z","timestamp":1777665548877,"version":"3.51.4"},"reference-count":61,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bone readiness for implant placement is typically evaluated by bone quality\/density on 2\u2010dimensional radiographs and cone beam computed tomography at an arbitrary time between 3 and 6\u00a0months after tooth extraction and alveolar ridge preservation (ARP). The aim of this study is to investigate if high\u2010frequency ultrasound (US) can classify bone readiness in humans, using micro\u2010CT as a reference standard to obtain bone mineral density (BMD) and bone volume fraction (BVTV) of healed sockets receiving ARP in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 27 bone cores were harvested during the implant surgery from 24 patients who received prior extraction with ARP. US images were taken immediately before the implant surgery at a site co\u2010registered with the tissue biopsy collection location, made possible with a specially designed guide, and then classified into 3 tiers using B\u2010mode image criteria (1) favorable, (2) questionable, and (3) unfavorable.\u00a0Bone mineral density (hydroxyapatite) and BVTV were obtained from micro\u2010CT as the gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hydroxyapatite and BVTV were evaluated within the projected US slice plane and thresholded to favorable (&gt;2200\u00a0mg\/cm<jats:sup>3<\/jats:sup>; &gt;0.45\u00a0mm<jats:sup>3<\/jats:sup>\/mm<jats:sup>3<\/jats:sup>), questionable (1500\u20132200\u00a0mg\/cm<jats:sup>3<\/jats:sup>; 0.4\u20130.45\u00a0mm<jats:sup>3<\/jats:sup>\/mm<jats:sup>3<\/jats:sup>), and unfavorable (&lt;1500\u00a0mg\/cm<jats:sup>3<\/jats:sup>; &lt;0.4\u00a0mm<jats:sup>3<\/jats:sup>\/mm<jats:sup>3<\/jats:sup>). The present US B\u2010mode classification inversely scales with BMD. Regression analysis showed a significant relation between US classification and BMD as well as BVTV. T\u2010test analysis demonstrated a significant correlation between US reader scores and the gold standard. When comparing Tier 1 with the combination of Tier 2 and 3, US achieved a significant group differentiation relative to mean BMD (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004, true positive 66.7%, false positive 0%, true negative 100%, false negative 33.3%, specificity 100%, sensitivity 66.7%, receiver operating characteristics area under the curve 0.86). Similar results were found between US\u2010derived tiers and BVTV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preliminary data suggest US could classify jawbone surface quality that correlates with BMD\/BVTV and serve as the basis for future development of US\u2010based socket healing evaluation after ARP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.23-0370","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T06:18:48Z","timestamp":1715667528000},"page":"1150-1159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ultrasound\u2010based jawbone surface quality evaluation after alveolar ridge preservation"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6011-6708","authenticated-orcid":false,"given":"Amanda B.","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver D.","family":"Kripfgans","sequence":"additional","affiliation":[{"name":"Department of Radiology Michigan Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth M.","family":"Kozloff","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Michigan Medical School  Ann Arbor Michigan USA"},{"name":"Department of Orthopedic Surgery University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankita","family":"Samal","sequence":"additional","affiliation":[{"name":"Department of Radiology Michigan Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010man","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Radiology Michigan Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Shehabeldin","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5952-0447","authenticated-orcid":false,"given":"Hsun\u2010Liang","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01703.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00366.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2913"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13390"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12173"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13057"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.5581"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12911"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.08.014"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.09.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20140238"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(92)90246-7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00642.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12082"},{"key":"e_1_2_9_16_1","first-page":"399","article-title":"Ridge preservation techniques to avoid invasive bone reconstruction: a systematic review and meta\u2010analysis: Naples Consensus Report Working Group C","volume":"12","author":"Barootchi S","year":"2019","journal-title":"Int J Oral Implantol (Berl)"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13121"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01705.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2241010948"},{"key":"e_1_2_9_20_1","first-page":"279","article-title":"Assessment of bone quality from cutting resistance during implant surgery","volume":"9","author":"Johansson P","year":"1994","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12315"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01280.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00932.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.166.2.3275985"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12829"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-4533(01)00097-2"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.211101"},{"key":"e_1_2_9_28_1","first-page":"208","article-title":"Bone density assessments of dental implant sites: 3. Bone quality evaluation during osteotomy and implant placement","volume":"22","author":"Lee S","year":"2007","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_9_29_1","first-page":"7","article-title":"Classification of partially edentulous arches for implant dentistry","volume":"4","author":"Misch CE","year":"1987","journal-title":"Int J Oral Implantol"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0746"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.6124"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zemedi.2023.01.005"},{"key":"e_1_2_9_33_1","first-page":"161","volume-title":"Dental Ultrasound in Periodontology and Implantology","author":"Chan H\u2010LA","year":"2020"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20190445"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13183"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(20)30459-4"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210602115010057"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04150609"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41747\u2010022\u201000286\u2010w"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1995.060305.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2021.08.008"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12918"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12805"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3913(12)60190-5"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20220044"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2021.07.006"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13758"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0342"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2011.11.028"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01873.x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.6.4.284"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13543"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106831\u201010\u201011"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/18200441"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.209.2.9807584"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13191-012-0189-7"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11548-014-1141-6"},{"key":"e_1_2_9_59_1","first-page":"131","volume-title":"Medical imaging2004: ultrasonic imaging and signal processing","author":"Jain AK","year":"2004"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/61\/1\/131"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-1681-5_2"},{"key":"e_1_2_9_62_1","first-page":"74","article-title":"Ultrasound imaging and segmentation of bone surfaces: a review","volume":"5","author":"Hacihaliloglu I","year":"2017","journal-title":"Technology (Singap World Sci)"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.23-0370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:37:34Z","timestamp":1760866654000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/JPER.23-0370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,14]]},"references-count":61,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/JPER.23-0370"],"URL":"https:\/\/doi.org\/10.1002\/jper.23-0370","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,14]]},"assertion":[{"value":"2023-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}