{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T15:33:06Z","timestamp":1769355186619,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study determined the prevalence of aggressive (molar\u2010incisor pattern) (Ag\/MI) periodontitis and assessed the associated subgingival bacterial\u2010herpesvirus microbiota in Pueblo Indian adolescents in the southwestern United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 240 Pueblo Indian adolescents, aged 13\u201320\u00a0years old, residing in three Rio Grande River villages in New Mexico and the Hopi Pueblo reservation in Arizona. Adolescents with Ag\/MI periodontitis or periodontal health provided subgingival samples for culture of bacterial pathogens and for polymerase chain reaction detection of periodontal herpesviruses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ag\/MI periodontitis was detected in 22 (9.2%) Pueblo Indian adolescents, with 21 exhibiting a localized molar\u2010incisor breakdown pattern. <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>, <jats:italic>Porphyromonas gingivalis<\/jats:italic>, and other red\/orange complex bacterial pathogens predominated in Ag\/MI periodontitis, whereas periodontal health yielded mainly viridans streptococci and <jats:italic>Actinomyces<\/jats:italic> species. Periodontal herpesviruses demonstrated a 3.5 odds ratio relationship with Ag\/MI periodontitis. The only adolescent with generalized Ag\/MI periodontitis harbored viral co\u2010infection by cytomegalovirus plus Epstein\u2013Barr virus Type 1, in addition to <jats:italic>A<\/jats:italic>. <jats:italic>actinomycetemcomitans<\/jats:italic>, <jats:italic>P<\/jats:italic>. <jats:italic>gingivalis<\/jats:italic>, and several other periodontopathic bacteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pueblo Indian adolescents showed an unusually high prevalence of early\u2010age Ag\/MI periodontitis predominated by periodontopathic bacteria and herpesviruses suspected to be major etiologic agents of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.23-0410","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T13:30:03Z","timestamp":1698845403000},"page":"594-602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Aggressive periodontitis in 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