{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:54:09Z","timestamp":1792068849995,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To compare acceptance and preference of topical lidocaine gel anesthesia with articaine injection anesthesia in patients with moderate periodontitis undergoing scaling and root debridement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010one patients completed this randomized multicenter split\u2010mouth controlled study and underwent two separate periodontal treatment sessions on different days, one with a topical intrapocket lidocaine gel application and the other with an articaine injection anesthesia in a different order depending on randomization. Parameters measured were the patients\u2019 preference for topical lidocaine gel anesthesia or injection anesthesia with articaine (primary efficacy criterion), their maximum and average pain, and their intensity of numbness as well as experience of side effects; the probing depth; and the dentists\u2019 preference and their evaluations of handling\/application, onset and duration of anesthetic effect, and patient compliance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After having experienced both alternatives, 58.3% of the patients preferred the topical lidocaine gel instillation into the periodontal pockets. The safety profile of the lidocaine gel differed positively from the safety profile of articaine injection in type and frequency of adverse drug reactions. The dentists\u02bc acceptance and preference regarding either anesthetic method studied were balanced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Instillation of lidocaine gel into the periodontal pocket is a preferred alternative to injection anesthesia for most of the patients and an equivalent alternative for dentists in nonsurgical periodontal therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.23-0466","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T11:43:17Z","timestamp":1712058197000},"page":"821-831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of acceptance and preference of topical lidocaine application versus articaine injection anesthesia after nonsurgical periodontal treatment: A randomized clinical trial"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2508-8075","authenticated-orcid":false,"given":"Christof","family":"D\u00f6rfer","sequence":"first","affiliation":[{"name":"Clinic for Conservative Dentistry and Periodontology University Hospital Schleswig\u2010Holstein, Campus Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Chmiela","sequence":"additional","affiliation":[{"name":"Clinic for Periodontology and Peri\u2010Implant Diseases Philipps University Marburg, UKGM  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole B.","family":"Arweiler","sequence":"additional","affiliation":[{"name":"Clinic for Periodontology and Peri\u2010Implant Diseases Philipps University Marburg, UKGM  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor J.","family":"Petersilka","sequence":"additional","affiliation":[{"name":"Dental 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