{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:55:21Z","timestamp":1791644121043,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Growing evidence suggests the type of periodontal treatment could differentially influence the reduction of key cardiovascular risk mediators in periodontitis patients. This randomized, controlled clinical trial compared the impact of minimally invasive non\u2010surgical therapy (MINST) with quadrant\u2010wise subgingival instrumentation (Q\u2010SI) on C\u2010reactive protein (CRP) together with lipoprotein\u2010associated phospholipase A\n 2<\/jats:sub>\n (Lp\u2010PLA\n 2<\/jats:sub>\n ) levels, and clinical periodontal outcomes in patients with periodontitis. Moreover, it was evaluated if baseline CRP levels impacted the efficacy of non\u2010surgical periodontal therapy protocols.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Forty\u2010two periodontitis patients were enrolled and randomly treated by means of MINST (\n n<\/jats:italic>\n \u00a0=\u00a021) or Q\u2010SI (\n n<\/jats:italic>\n \u00a0=\u00a021). The outcomes assessed were serum CRP and Lp\u2010PLA\n 2<\/jats:sub>\n , and periodontal parameters (probing depth [PD], clinical attachment level [CAL], full\u2010mouth bleeding score [FMBS]), at baseline and at follow\u2010ups at 1, 3, and 6 months and at 1 year after treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At 1 year, MINST significantly reduced, among others, mean PD (\n p<\/jats:italic>\n \u00a0=\u00a00.007), mean CAL (\n p<\/jats:italic>\n \u00a0=\u00a00.007), the number of pockets\u00a0>4\u00a0mm (\n p<\/jats:italic>\n \u00a0=\u00a00.011) and \u22656\u00a0mm (\n p<\/jats:italic>\n \u00a0=\u00a00.005), and FMBS (\n p<\/jats:italic>\n \u00a0=\u00a00.048) compared to Q\u2010SI. Generalized multivariate analysis evidenced that high baseline CRP (\n p<\/jats:italic>\n \u00a0=\u00a00.039) and FMBS (\n p<\/jats:italic>\n \u00a0=\u00a00.046) levels, together with MINST treatment (\n p<\/jats:italic>\n \u00a0=\u00a00.007) were significant predictors of PD reduction at 1\u2010year follow\u2010up. Moreover, the Jonckheere\u2013Terpstra test showed that patients with high baseline CRP levels gained more benefits from MINST treatment at 1\u2010year follow\u2010up than they did from Q\u2010SI.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Patients receiving MINST showed a greater reduction in CRP levels than patients with Q\u2010SI after 1 year of follow\u2010up. Moreover, patients with high baseline levels of CRP and Lp\u2010PLA\n 2<\/jats:sub>\n gained more benefits from the MINST approach at 1\u2010year follow\u2010up.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jper.23-0518","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T14:14:22Z","timestamp":1714659262000},"page":"949-962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Effects of minimally invasive non\u2010surgical therapy on C\u2010reactive protein, lipoprotein\u2010associated phospholipase A\n 2<\/sub>\n , and clinical outcomes in periodontitis patients: A 1\u2010year randomized, controlled clinical trial"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-6992","authenticated-orcid":false,"given":"Gaetano","family":"Isola","sequence":"first","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties, Unit of Periodontology, School of Dentistry University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pesce","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC) University of Genoa, Ospedale San Martino Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Polizzi","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties, Unit of Periodontology, School of Dentistry University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Lo Giudice","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties, Unit of Periodontology, School of Dentistry University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cicci\u00f9","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties, Unit of Periodontology, School of Dentistry University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8804-6593","authenticated-orcid":false,"given":"Frank A.","family":"Scannapieco","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, School of Dental Medicine University at Buffalo, The State University of New York Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13021"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0049"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13078"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13189"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0403"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13245"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0855-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3544-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2810264"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-04994-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-03841-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12786"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2021.04.007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00731.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.05.035"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13770"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13760"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00822.x"},{"key":"e_1_2_9_22_1","unstructured":"Excessive Alcohol Use. 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