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This study evaluates serum samples from RA cases and osteoarthritis (OA) controls to quantify associations between periodontal clinical measures, alveolar bone loss (ABL), and anti\u2010<jats:italic>Porphyromonas gingivalis<\/jats:italic>, anti\u2010<jats:italic>Prevotella intermedia<\/jats:italic>, and anti\u2010<jats:italic>Fusobacterium nucleatum<\/jats:italic> antibody concentrations with anti\u2010MAA antibody concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a0284 RA cases, <jats:italic>n<\/jats:italic>\u00a0=\u00a0330 OA controls) underwent periodontal clinical assessments and ABL measurements. Serum immunoglobulin (Ig) A, IgG, and IgM anti\u2010MAA and serum IgG antibacterial antibody concentrations were quantified by enzyme\u2010linked immunosorbent assay (ELISA). Analyses utilized simple linear regression and multivariable adjusted models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant associations of periodontal clinical measures with serum anti\u2010MAA were found. Moderate (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.038 and <jats:italic>p\u00a0<\/jats:italic>=\u00a00.036, respectively) and high ABL (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.012 and <jats:italic>p\u00a0<\/jats:italic>=\u00a00.014, respectively) in RA cases (but not in OA) were positively associated with IgG and IgM anti\u2010MAA. Anti\u2010<jats:italic>P. gingivalis<\/jats:italic> and anti\u2010<jats:italic>P. intermedia<\/jats:italic> antibody concentrations were positively associated with IgA (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.001 for both), IgG (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.007 and <jats:italic>p\u00a0<\/jats:italic>=\u00a00.034, respectively), and IgM anti\u2010MAA antibody concentrations (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 and <jats:italic>p\u00a0<\/jats:italic>=\u00a00.020, respectively), while anti\u2010<jats:italic>F. nucleatum<\/jats:italic> was positively associated with IgG anti\u2010MAA (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.042), findings that were similar across groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A positive association was demonstrated between ABL and serum IgG and IgM anti\u2010MAA antibody concentrations that was unique to RA and not observed in OA. Serum anti\u2010<jats:italic>P. gingivalis<\/jats:italic>, anti\u2010<jats:italic>P. intermedia<\/jats:italic>, and anti\u2010<jats:italic>F. nucleatum<\/jats:italic> antibody concentrations displayed significant associations with anti\u2010MAA antibody in both groups. These findings suggest MAA may play a role in the interrelationship between the periodontium and RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.23-0604","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T12:03:44Z","timestamp":1715342624000},"page":"929-941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Associations between periodontitis and serum anti\u2010malondialdehyde\u2013acetaldehyde antibody concentrations in rheumatoid arthritis: A case\u2010control study"],"prefix":"10.1002","volume":"95","author":[{"given":"Joyce A.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgical Specialties Division of Periodontics College of Dentistry University of Nebraska Medical Center  Lincoln Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted R.","family":"Mikuls","sequence":"additional","affiliation":[{"name":"Department of 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