{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:17:19Z","timestamp":1789888639742,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Implant surface decontamination is a critical step in peri\u2010implantitis treatment. The aim of this study was to assess the effect chemotherapeutic agents have on reosseointegration after treatment on ligature\u2010inducted peri\u2010implantitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six male canines had 36 implants placed and ligatures were placed around them for 28 weeks to establish peri\u2010implantitis. The peri\u2010implant defects were randomly treated by 1 of 3 methods: 0.12% chlorhexidine (CHX test group), 1.5% sodium hypochlorite (NaOCl test group), or saline (Control group). Sites treated with NaOCl and CHX were grafted with autogenous bone, and all sites then either received a collagen membrane or not. Histology sections were obtained at 6 months postsurgery to assess percentage of reosseointegration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five implants were analyzed (CHX: 13; NaOCl: 14; Control:8). NaOCl\u2010treated sites demonstrated reosseointegration with direct bone\u2010to\u2010implant\u2010contact on the previously contaminated surfaces (42% mean reosseointegration), which was significantly higher than Controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Correspondingly, clinical improvement was noted with a significant reduction in probing depth from 5.50\u00a0\u00b1\u00a01.24\u00a0mm at baseline to 4.46\u00a0\u00b1\u00a01.70\u00a0mm at 6\u2010months postsurgery (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006). CHX\u2010treated sites demonstrated a nonsignificant reosseointegration of 26% (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05); however, in the majority of cases, the new bone growth was at a distance from the implant surface without contact. Probing depths did not improve in the CHX group. The use of membrane did not influence reosseointegration or probing depths (all <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Titanium implants with peri\u2010implantitis have the capacity to reosseointegrate following regenerative surgery. However, treatment response is contingent upon the chemotherapeutic agent selection. Additional chemical treatment with 1.5% NaOCl lead to the most favorable results in terms of changes in defect depth and percentage of reosseointegration as compared to CHX, which may hinder reosseointegration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.23-0634","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T01:12:13Z","timestamp":1718586733000},"page":"991-1001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of surface chemical treatment in surgical regenerative treatment of ligature\u2010induced peri\u2010implantitis: A canine study"],"prefix":"10.1002","volume":"95","author":[{"given":"Shu\u2010Jiao","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillo\u2010Facial Implantology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine; College of Stomatology Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9700-4056","authenticated-orcid":false,"given":"Yi\u2010Wen","family":"Tsai","sequence":"additional","affiliation":[{"name":"ITI Scholarship Center, University of Texas Health Science Center San Antonio  San Antonio Texas USA"},{"name":"Department of Periodontology School of Dentistry Tri\u2010Service General Hospital and National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theofilos","family":"Koutouzis","sequence":"additional","affiliation":[{"name":"Department of Periodontics Nova Southeastern University  Fort Lauderdale Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Chang","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillo\u2010Facial Implantology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine; College of Stomatology Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Chong","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillo\u2010Facial Implantology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine; College of Stomatology Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8635-9422","authenticated-orcid":false,"given":"Georgios A.","family":"Kotsakis","sequence":"additional","affiliation":[{"name":"ITI Scholarship Center, University of Texas Health Science Center San Antonio  San Antonio Texas USA"},{"name":"Department of Oral Biology &amp; Clinical Research Center Rutgers School of Dental Medicine  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517740560"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120592"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13903"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.130610"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00956.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01655.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01762.x"},{"key":"e_1_2_9_10_1","article-title":"Interventions for replacing missing teeth: treatment of peri\u2010implantitis","volume":"1","author":"Esposito M","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01283.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40496-020-00279-x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12308"},{"key":"e_1_2_9_14_1","first-page":"9","article-title":"Bone regeneration adjacent to titanium dental implants using guided tissue regeneration: a report of two cases","volume":"5","author":"Nyman S","year":"1990","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01742.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13070"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515610056"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.16-0350"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01661.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12049"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150684"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150476"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12566"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.10.984"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.4923"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01820.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.120607.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1999.100302.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.01.005"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12332"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1999.100303.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0186"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.11.1498"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"ca","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.23-0634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:38:33Z","timestamp":1760877513000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/JPER.23-0634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,16]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/JPER.23-0634"],"URL":"https:\/\/doi.org\/10.1002\/jper.23-0634","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,16]]},"assertion":[{"value":"2023-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}