{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:12:47Z","timestamp":1792109567739,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Studies on the impact of intermittent fasting on periodontal health are still scarce. Thus, this study evaluated the effects of long\u2010term intermittent fasting on periodontal health and the subgingival microbiota.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This pilot study was part of a nonrandomized controlled trial. Overweight\/obese participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a014) entered an intermittent fasting program, specifically the 5:2 diet, in which they restricted caloric intake to about a quarter of the normal total daily caloric expenditure for two nonconsecutive days\/week. Subjects underwent a thorough clinical and laboratory examination, including an assessment of their periodontal condition, at baseline and 6\u00a0months after starting the diet. Additionally, subgingival microbiota was assessed by 16S rRNA gene sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 6\u00a0months of intermittent fasting, weight, body mass index, C\u2010reactive protein, hemoglobin A1c (HbA1c), and the cholesterol profile improved significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Moreover, significant reductions were observed in bleeding on probing (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) and the presence of shallow periodontal pockets after fasting (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), while no significant change was seen in plaque index (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.14). While we did not observe significant changes in \u03b1\u2010 or \u03b2\u2010diversity of the subgingival microbiota related to dietary intervention (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05), significant differences were seen in the abundances of several taxa among individuals exhibiting \u226560% reduction (good responders) in probing pocket depth of 4\u20135\u00a0mm compared to those with &lt;60% reduction (bad responders).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intermittent fasting decreased systemic and periodontal inflammation. Although the subgingival microbiota was unaltered by this intervention, apparent taxonomic variability was observed between good and bad responders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.23-0676","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T04:15:56Z","timestamp":1713932156000},"page":"640-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of intermittent fasting on periodontal inflammation and subgingival microbiota"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0297-5138","authenticated-orcid":false,"given":"Ronaldo","family":"Lira\u2010Junior","sequence":"first","affiliation":[{"name":"Section of Oral Diagnostics and Surgery Division of Oral Diagnostics and Rehabilitation Department of Dental Medicine Karolinska Institutet  Stockholm 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