{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:14:27Z","timestamp":1791756867458,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100977"],"award-info":[{"award-number":["82100977"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To explore the correlation between short\u2010chain fatty acids (SCFAs) in the peri\u2010implant sulcular fluid (PISF) and peri\u2010implant diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PISF samples were obtained from implants that have been placed for at least 5\u00a0years, and peri\u2010implant clinical parameters were examined. Gas chromatography\u2010mass spectrometry and high\u2010performance liquid chromatography were used to detect SCFAs in PISF. The correlation between SCFAs and clinical parameters was analyzed by Spearman's correlation. SCFAs related to peri\u2010implant disease were identified by logistic regression and ranked by random forest analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010six implants were divided into a peri\u2010implant health group (PIH\u2010group, 35 implants), peri\u2010implant mucositis group (PIM\u2010group, 25 implants), and peri\u2010implantitis group (PI\u2010group, 26 implants) according to clinical and radiographic examination results. The PIM\u2010group had significantly lower formic acid detection rate than the other two groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). The PIM\u2010group had significantly higher levels of acetic, propionic, and isovaleric acids than the PIH\u2010group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The PI\u2010group had significantly higher levels of propionic, butyric, isobutyric, valeric, and isovaleric acids than the PIH\u2010group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The PI\u2010group had significantly higher levels of butyric, isobutyric, and isovaleric acids than the PIM\u2010group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). SCFAs (apart from hexanoic and succinic acids) were significantly and positively correlated with clinical parameters (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). SCFAs related to peri\u2010implant disease were ranked as follows: butyric, isovaleric, isobutyric, propionic, acetic, formic, and lactic acids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated specific SCFAs are correlated with peri\u2010implant disease. Recognition of this correlation may help in early identification of peri\u2010implant disease and guide further clinical interventions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.23-0682","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T01:39:22Z","timestamp":1718933962000},"page":"21-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Correlation between short\u2010chain fatty acids and peri\u2010implant disease: A cross\u2010sectional study"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6670-7055","authenticated-orcid":false,"given":"Yue","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Implantology &amp; Human Microbiome &amp; Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University &amp; Shandong Key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Implantology &amp; Human Microbiome &amp; Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University &amp; Shandong Key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Implantology &amp; Human Microbiome &amp; Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University &amp; Shandong Key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Implantology &amp; Human Microbiome &amp; Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University &amp; Shandong Key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiwen","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Implantology &amp; Human Microbiome &amp; Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University &amp; Shandong Key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengben","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Implantology &amp; Human Microbiome &amp; Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University &amp; Shandong Key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Implantology &amp; Human Microbiome &amp; Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University &amp; Shandong Key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"},{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Implantology &amp; Human Microbiome &amp; Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University &amp; Shandong Key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-5480","authenticated-orcid":false,"given":"Shaohua","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Implantology &amp; Human Microbiome &amp; 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