{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:26:35Z","timestamp":1771028795917,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The composite outcome measure (COM) more comprehensively assesses the clinical efficacy of regenerative surgery than a single probing measurement. We aimed to assess long\u2010term success defined by the COM (clinical attachment level [CAL] gain of \u22653\u00a0mm and postsurgery probing pocket depth [PPD] \u2264 4\u00a0mm) and influencing factors of regenerative surgery using bone substitutes and resorbable collagen membrane (RM) for intra\u2010bony defects (IBDs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively collected data from patients who underwent regenerative surgery using deproteinized bovine bone mineral (DBBM) and RM for IBDs. CAL and PPD values were compared at baseline (preoperative), 1 year (short\u2010term), and at the last follow\u2010up (5\u201310 years). Multivariate logistic regressions were performed to identify factors influencing COM\u2010based long\u2010term success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010one defects in 75 teeth of 33 patients who completed follow\u2010up (6.5\u00a0\u00b1\u00a01.4 years) were included. One tooth was lost. All defects with complete follow\u2010up exhibited long\u2010term average CAL gain (3.00\u00a0\u00b1\u00a02.00\u00a0mm, 95% confidence interval [CI]: 2.56\u20133.44\u00a0mm, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001) and PPD reduction (2.06\u00a0\u00b1\u00a01.91\u00a0mm, 95% CI: 1.64\u20132.49\u00a0mm, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). Long\u2010term success was achieved in 38.8% of IBDs. CAL and PPD values were comparable between 1 year and the last follow\u2010up. Logistic regression analyses revealed that male sex (odds ratio [OR]\u00a0=\u00a00.23, 95% CI: 0.07\u20130.75) and bleeding on probing (BOP) during supportive periodontal therapy (OR\u00a0=\u00a00.96, 95% CI: 0.94\u20130.99) were risk factors for long\u2010term success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Regenerative surgery with DBBM and RM for IBDs can achieve some degree of long\u2010term success defined by COM. However, within this study's limitations, male sex and higher BOP incidence postoperatively are negatively associated with optimal long\u2010term success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial number<\/jats:title><jats:p>ChiCTR2300069016.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.23-0701","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:01:22Z","timestamp":1719532882000},"page":"129-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term success and influencing factors of regenerative surgery for intra\u2010bony defects: A retrospective cohort study"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9166-1225","authenticated-orcid":false,"given":"Yan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; 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National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140378"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0288"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13381"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04134-w"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00911.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070282"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01007.x"},{"key":"e_1_2_10_9_1","first-page":"229","article-title":"Long\u2010term stability of adjunctive use of enamel matrix protein derivative on porcine\u2010derived xenograft for the treatment of one\u2010wall intrabony defects: a 4\u2010year extended follow\u2010up of a randomized controlled trial","volume":"93","author":"Lee JH","year":"2022","journal-title":"J Periodontol"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13814"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13627"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0127"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0347"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.060029"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2208-x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100297"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-016-0250-9"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0721"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13639"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.7.658"},{"key":"e_1_2_10_22_1","first-page":"125","volume-title":"Textbook of Periodontia","author":"Miller SC","year":"1950"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12048"},{"key":"e_1_2_10_24_1","first-page":"7","article-title":"Periodontal risk assessment (PRA) for patients in supportive periodontal therapy (SPT)","volume":"1","author":"Lang NP","year":"2003","journal-title":"Oral Health Prev Dent"},{"key":"e_1_2_10_25_1","first-page":"S111","article-title":"6. 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