{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:14:52Z","timestamp":1761948892640,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201066"],"award-info":[{"award-number":["82201066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021JJ40390"],"award-info":[{"award-number":["2021JJ40390"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to investigate the relationship between the pan\u2010immune\u2010inflammation value (PIV) and periodontitis based on a large national survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present cross\u2010sectional study, data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2009\u20132014, which included a total of 10,300 participants. The categorization of periodontitis was based on the 2017 classification scheme. The PIV was determined using the formula: (neutrophils count \u00d7 monocyte count \u00d7 platelet count)\/lymphocytes count. Restricted cubic spline and weighted multivariable logistic regression analyses were employed to evaluate the associations between the PIV with periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The associations between PIV and stage III\/IV periodontitis followed a U\u2010shaped pattern (<jats:italic>P<\/jats:italic><jats:sub>non\u2010linearity<\/jats:sub>\u00a0&lt;\u00a00.001). The risk of developing stage III\/IV periodontitis showed an increasing trend among participants in the first quartile (odds ratio [OR]\u00a0=\u00a01.21; 95% confidence interval [CI]: 1.01\u20131.46), third quartile (OR\u00a0=\u00a01.34; 95% CI: 1.11\u20131.61), and fourth quartile (OR\u00a0=\u00a01.47; 95% CI: 1.25\u20131.73) compared to those in the second quartile. Subgroup analysis indicated stronger associations of PIV with periodontitis in males (OR<jats:sub>Q4vs2<\/jats:sub>\u00a0=\u00a01.72, 95% CI: 1.36\u20132.18) and individuals with hypertension (OR<jats:sub>Q4vs2<\/jats:sub>\u00a0=\u00a01.78, 95% CI: 1.38\u20132.28) with significant interactions (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a U\u2010shaped association between PIV and stage III\/IV periodontitis, which suggests a potential adjunctive treatment strategy for periodontitis. Higher PIV values were found to have a stronger correlation with stage III\/IV periodontitis in males and individuals with hypertension. Further prospective trials are needed to confirm the validity of our results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>A U\u2010shaped association exists between the pan\u2010immune inflammation value and periodontitis in US adults, suggesting that maintaining a moderate immune inflammation response is crucial for periodontal health.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.24-0318","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:30:21Z","timestamp":1722990621000},"page":"184-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["U\u2010shaped association between pan\u2010immune\u2010inflammation value and periodontitis: NHANES 2009\u20132014"],"prefix":"10.1002","volume":"96","author":[{"given":"Huan","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University  Xi'an China"},{"name":"Department of Periodontology College of Stomatology Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Hunan University of Medicine  Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Miao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University  Xi'an China"},{"name":"Department of Periodontology College of Stomatology Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoyan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Periodontics Liaoning Provincial Key Laboratory of Oral Diseases School and Hospital of Stomatology China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12368"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12430"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.664756"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-024-05529-1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.23-0260"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13872"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S421491"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00122-9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1326083"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12946"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12945"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0620"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0399"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110664"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-019-0064-z"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12313"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00086"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700672"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100044"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100045"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00964-1"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpv034"}],"container-title":["Journal 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