{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:45:49Z","timestamp":1776059149914,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peri\u2010implantitis is a destructive disease affecting the tissues surrounding dental implants. Biomaterials may be applied during surgical treatment to reconstruct bony defects and support soft tissue healing. However, current evidence is unclear if these treatments increase the likelihood of peri\u2010implantitis resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis was performed on randomized controlled trials (RCTs) comparing surgical treatment with addition of reconstructive biomaterials (intervention) versus surgical treatment of peri\u2010implantitis alone (comparison) with follow\u2010up periods of at least 12 months. Resolution of peri\u2010implantitis, defined as a reduction of probing pocket depth (PPD) to \u22645\u00a0mm, absence bleeding on probing (BOP), and stable or decreasing radiographic defect level (RDL), was selected as the primary outcome. Secondary outcomes included RDL reduction, buccal mucosal recession (REC), and patient\u2010related outcome measures (PROMs). Risk of bias and quality of evidence were calculated using established guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven studies reporting on 402 patients with 405 implants met inclusion criteria. Wide variations in outcome reporting prevented the synthesis and quantitative comparison of peri\u2010implantitis disease resolution between intervention and comparison groups. Individual meta\u2010analyses showed a weighted mean difference (WMD) in PPD reduction of 0.28\u00a0mm [95% confidence interval (CI) \u20100.30, 0.86] and a relative risk (RR) for absence of BOP of 1.11 (95% CI 0.78, 1.59) for the inclusion of biomaterials (intervention) over access flap alone (comparison). For RDL reduction, a WMD of 1.08\u00a0mm (95% CI 0.41, 1.74) with significant heterogeneity (Q\n                      <jats:italic>p<\/jats:italic>\n                      \u2010val:\u00a0&lt;\u00a00.01,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      : 85%) and for REC, a WMD of \u20100.38 (95% CI \u22120.66, \u22120.11) was found, both in favor of the intervention. Analysis of the heterogeneity affecting RDL identified a positive effect on RDL when hydrogen peroxide but not rotary titanium brushes were used as an adjunct for implant surface debridement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current evidence suggests that incorporating reconstructive biomaterials into surgical treatment may not definitively enhance the likelihood of peri\u2010implantitis disease resolution. However, this lack of effect may be due to other factors such as implant surface treatments which may also affect clinical outcomes. Overall, this work highlights the critical need for standardizing the reporting of composite outcomes for the resolution of peri\u2010implantitis disease and controlling for implant surface treatment effects when assessing reconstructive biomaterials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain language summary<\/jats:title>\n                    <jats:p>Peri\u2010implantitis is a destructive disease affecting tissues around dental implants. We studied whether adding reconstructive biomaterials (i.e., biomaterials used to improve the likelihood of new bone formation or bone defect fill) to surgical treatments improves the clinical condition, meaning no further bone loss, probing pocket depths (PPD) \u22645\u00a0mm, and no bleeding on probing (BOP). We reviewed randomized controlled trials (RCTs) comparing surgery with biomaterials to surgery alone with at least 12 months of follow\u2010up. The main outcomes measured were PPD reduction, absence of BOP, and radiographic defect level (RDL). Secondary outcomes included RDL change, buccal mucosal recession (REC), and patient\u2010related outcomes (PROMs). Seven studies with 402 patients and 405 implants were analyzed. Due to variations in outcome reporting, it was challenging to compare the effectiveness of treatments. However, some individual analyses showed a small improvement in PPD and BOP with biomaterials. For RDL reduction, biomaterials showed better results, but with significant variability. REC also improved slightly with biomaterials. The analysis also suggested that using hydrogen peroxide, but not rotary titanium brushes, for implant cleaning could positively affect bone levels. The study concluded that adding biomaterials to surgical treatment does not definitively improve peri\u2010implantitis resolution, possibly due to other factors like implant surface treatments. This study emphasized the need for standardized reporting and considering these factors in future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.24-0432","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:56:46Z","timestamp":1774879006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomaterials for resolution of peri\u2010implantitis: Consensus report of Workgroup 2 of the IADR Implantology Research Group Best Evidence Consensus Symposium on Peri\u2010Implant Disease and Its Treatment"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6303-7287","authenticated-orcid":false,"given":"Sukirth M.","family":"Ganesan","sequence":"first","affiliation":[{"name":"Department of Periodontics University of Iowa College of Dentistry  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-2503","authenticated-orcid":false,"given":"David R.","family":"Fraser","sequence":"additional","affiliation":[{"name":"National Institute of Dental and Craniofacial Research National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7498-8064","authenticated-orcid":false,"given":"Mustafa","family":"Tattan","sequence":"additional","affiliation":[{"name":"Department of Periodontics University of Iowa College of Dentistry  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2231-7239","authenticated-orcid":false,"given":"Jessica M.","family":"Latimer","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine, Infection, and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"IADR IRG Peri\u2010Implantitis Best Evidence Consensus Working Group 2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8635-9422","authenticated-orcid":false,"given":"Georgios","family":"Kotsakis","sequence":"additional","affiliation":[{"name":"Department of Oral Biology Rutgers School of Dental Medicine  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.16-0350"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12069"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01837.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12417"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13070"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12523"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/apnr.2002.34181"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13972"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13513"},{"issue":"7","key":"e_1_2_10_17_1","first-page":"546","article-title":"D\u2010PLEX500: a local biodegradable prolonged release doxycycline\u2010formulated bone graft for the treatment for peri\u2010implantitis. 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