{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:00:04Z","timestamp":1785812404827,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periodontitis is a chronic inflammatory condition that affects the supporting structures of the teeth. It is closely associated with oxidative stress and inflammation. Taurine, a semi\u2010essential amino acid recognized for its antioxidant and anti\u2010inflammatory properties, has not been extensively investigated in the context of periodontitis. This pilot study sought to evaluate the levels of taurine and inflammatory cytokines, including interleukin\u20101 beta (IL\u20101\u03b2), interleukin\u20106 (IL\u20106), and tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), in the gingival crevicular fluid (GCF) of individuals with periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systemically healthy participants with periodontitis and periodontally healthy individuals were enrolled. GCF samples were collected, and clinical periodontal parameters such as bleeding on probing (BOP), clinical attachment loss (CAL), plaque index (PI), and probing depth (PD) were documented. The levels of taurine, TNF\u2010\u03b1, IL\u20101\u00df, and IL\u201016 in the GCF were quantified using enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This case\u2010control pilot study included 40 individuals, divided into 2 groups: 20 periodontally healthy individuals and 20 with stage III, grade B generalized periodontitis. The periodontitis group exhibited significantly higher clinical periodontal parameters than the healthy group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Taurine levels in GCF were significantly lower, while TNF\u2010\u03b1 levels were higher in the periodontitis group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). No significant differences between groups were found in IL\u20106 and IL\u20101\u03b2 levels (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). A moderate positive correlation was observed between BOP and TNF\u2010\u03b1 levels (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.581, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings indicated increased taurine levels were associated with periodontal health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>Periodontitis is a serious disease of the gums that can lead to the loss of teeth by destruction of the supporting tissues.\u00a0This study investigated the potential link between taurine, a naturally occurring compound with anti\u2010inflammatory properties, and periodontitis. We measured levels of taurine and inflammation\u2010related proteins in gum fluid from individuals with healthy gums and those with periodontitis. Subjects with periodontitis had lower levels of taurine and higher levels of the inflammatory protein TNF\u2010\u03b1 compared to individuals with healthy gums, suggesting that taurine could be involved in the inflammation processes of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.24-0574","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T21:01:37Z","timestamp":1743368497000},"page":"984-993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Taurine levels in periodontitis: A pilot study"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0554-9567","authenticated-orcid":false,"given":"Mehmet Fatih","family":"D\u00f6nmez","sequence":"first","affiliation":[{"name":"Vocational School of Health Services Department of Dental Services Toros University  Mersin 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