{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:36:19Z","timestamp":1778175379568,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Collagenated bovine bone mineral (CBBM) is used for maxillary sinus elevation\u2010based augmentation. We compared collagen degradation in cross\u2010linked (CL) CBBM and non\u2010cross\u2010linked (NCL) CBBM (in vitro) and preclinical results in CBBM\u2010CL, CBBM\u2010NCL, deproteinized bovine bone mineral (DBBM), and DBBM with fibrin sealant grafts (in vivo) after repair of perforated Schneiderian membrane (SM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Collagenase\u2010based degradation rates of CBBM\u2010CL and CBBM\u2010NCL were compared in vitro and in vivo (CBBM\u2010CL, CBBM\u2010NCL, DBBM, and DBBM with fibrin glue;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a012 defects per group). After bilateral maxillary SM perforation (5\u00a0mm) during sinus elevation, we performed bone substitute\u2010based augmentation. At 4 and 12\u00a0weeks postoperatively, volumetric, histologic, and histomorphometric analyses were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Complete degradation and 33% retention of collagen content after 24 and 72\u00a0h were noted in CBBM\u2010NCL and CBBM\u2010CL, respectively. CBBM\u2010NCL demonstrated significant differences in total augmentation volume (TAV) compared to DBBM and DBBM with fibrin glue, as well as in new bone volume (NBV) compared to DBBM with fibrin glue. At 12\u00a0weeks, significant differences were observed between CBBM\u2010NCL and DBBM in NBV. There were no significant differences across all groups in vertical bone increase in 4 and 12\u00a0weeks. DBBM and DBBM with fibrin glue showed more irregularly shaped patterns than CBBM\u2010CL and CBBM\u2010NCL. At 12\u00a0weeks, ossification progressed in all groups. At 4\u00a0weeks, DBBM with fibrin glue seemed to demonstrate early ossification at the perforation site in histological observations compared to DBBM alone; however, no differences were observed at 12\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CBBM for perforated SM repair confers bone stability and ossification. CBBM\u2010CL was noninferior to CBBM\u2010NCL in volume stability. The findings indicate that the CL collagen in CBBM\u2010CL contributes to enhanced graft stability over time. Fibrin glue appeared to have a positive effect on early ossification in histological evaluations, but this effect was not evident at 12\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary<\/jats:title>\n                    <jats:p>Collagenated bovine bone mineral (CBBM) is used for maxillary sinus elevation\u2010based augmentation. We compared collagen degradation in cross\u2010linked (CL) CBBM and non\u2010cross\u2010linked (NCL) CBBM (in vitro) and preclinical results in CBBM\u2010CL, CBBM\u2010NCL, deproteinized bovine bone mineral (DBBM), and DBBM with fibrin sealant (in vivo) after repair of perforated Schneiderian membrane (SM). After bilateral maxillary SM perforation (5\u00a0mm) during sinus elevation, we performed bone substitute\u2010based augmentation. At 4 and 12\u00a0weeks postoperatively, volumetric, histologic, as well as histomorphometric analyses were performed. Based on this study, CL collagen in CBBM\u2010CL contributes to enhanced graft stability over time. Fibrin glue appeared to have a positive effect on early ossification in histological evaluations, but this effect was not evident at 12\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.24-0663","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T08:11:45Z","timestamp":1743754305000},"page":"1154-1167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of four bone substitute types in sinus augmentation with perforated Schneiderian membrane: An experimental study"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5383-3004","authenticated-orcid":false,"given":"Jung\u2010Tae","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Periodontics One\u2010Stop Specialty Center Seoul National University Dental Hospital  Jongno\u2010gu Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7473-9882","authenticated-orcid":false,"given":"Seok Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Xenograft Development Team Tissue Regeneration Institute Osstem Implant Co. Ltd.  Gangseo\u2010gu Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7129-4846","authenticated-orcid":false,"given":"Baek Sun","family":"Choi","sequence":"additional","affiliation":[{"name":"Xenograft Development Team Tissue Regeneration Institute Osstem Implant Co. Ltd.  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