{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:25:27Z","timestamp":1791465927719,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peri\u2010implantitis has become an important health issue in implant dentistry in the past years. Despite the magnitude of this problem and the potential grave consequences, the predictability and long\u2010term stability of its treatment is still a matter of controversy. The aim of this study was to assess clinical and radiographic results 5 years after the peri\u2010implantitis reconstructive treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 5\u2010year follow\u2010up observational study was carried out on patients who had been included in a previous randomized clinical study evaluating the effectiveness of a titanium brush in the peri\u2010implantitis reconstructive treatment. The reconstruction was carried out by means of an alloplastic graft and a collagen membrane. The primary outcome was the reduction in probing pocket depth at the deepest site (PDd).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 17 patients were available for evaluation. An overall reduction of 2.86\u00a0mm (SD 2.27) and 4.10\u00a0mm (SD 1.79) in PDd was noted for control and test group, which means an increase of 0.14\u00a0mm (SD 1.07) and 1.30\u00a0mm (SD 1.77) from data reported at 12 months (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.159), respectively. A lower bleeding index and daily use of interdental brushes were significantly associated with lower probing depth (PD) values. There was bone loss in both groups of less than 0.5\u00a0mm, and radiographic bone fill represented 32.77% (SD 48.18) and 54.91% (SD 51.49) of the initial defect in the control and test group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although with a slight progression, PD reduction can be maintained after the reconstructive treatment around dental implants 5 years after treatment. The trial was registered at ClinicalTrials.gov (NCT03512730).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain language summary<\/jats:title>\n                    <jats:p>Treatment of peri\u2010implantitis, specifically reconstructive surgical treatment has been widely investigated. Nevertheless, the paucity of long\u2010term studies reporting on the adjunctive use of a titanium brush in the reconstructive treatment of peri\u2010implantitis underscores the need for further research to validate its effectiveness and long\u2010term benefits.<\/jats:p>\n                    <jats:p>To assess outcomes, stability, and real added benefit of this tool, long term results are of substantial value. Moreover, long\u2010term studies assessing outcomes after reconstructive treatment in peri\u2010implantitis lesions are specially needed taking into account their scarceness in the scientific literature.<\/jats:p>\n                    <jats:p>Five years post\u2010treatment, peri\u2010implantitis reconstructive therapy with a titanium brush showed significant PD reductions (2.86\u00a0mm in control, 4.10\u00a0mm in test group) and minor bone loss (&lt;\u00a00.5\u00a0mm); however, no significant differences were found between groups. Radiographic bone fill was 32.77% in the control group and 54.91% in the test group. Lower bleeding index and daily interdental brush use correlated with better outcomes, indicating sustained improvements.<\/jats:p>\n                    <jats:p>Based on the study's findings, incorporating a titanium brush in the reconstructive treatment of peri\u2010implantitis could enhance long\u2010term outcomes. Highlighting the significance of interdental brush daily use and maintaining a low bleeding index may further improve treatment success.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.24-0673","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T21:00:01Z","timestamp":1743368401000},"page":"1213-1226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Peri\u2010implantitis reconstructive treatment implementing a titanium brush: 5\u2010year extension results from a randomized clinical trial"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5542-7659","authenticated-orcid":false,"given":"Beatriz","family":"de Tapia","sequence":"first","affiliation":[{"name":"Department of Periodontology Universitat International de Catalunya Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4663-5979","authenticated-orcid":false,"given":"Tiago","family":"Ribeiro\u2010Amaral","sequence":"additional","affiliation":[{"name":"Department of Periodontology Universitat International de Catalunya Barcelona Spain"},{"name":"Department of Periodontology Universidade de Lisboa Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5914-1495","authenticated-orcid":false,"given":"Carolina","family":"Mor","sequence":"additional","affiliation":[{"name":"Department of Periodontology Universitat International de Catalunya Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2363-4992","authenticated-orcid":false,"given":"Jos\u00e9","family":"Nart","sequence":"additional","affiliation":[{"name":"Department of Periodontology Universitat International de Catalunya Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-1208","authenticated-orcid":false,"given":"Cristina","family":"Valles","sequence":"additional","affiliation":[{"name":"Department of Periodontology Universitat International de Catalunya Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"S267","DOI":"10.1002\/JPER.16-0350","article-title":"Peri\u2010implantitis","volume":"89","author":"Schwarz F","year":"2018","journal-title":"J Periodontol"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcpe.13823","article-title":"Prevention and treatment of peri\u2010implant diseases\u2010The EFP S3 level clinical practice guideline","volume":"50","author":"Herrera D","year":"2023","journal-title":"J Clin Periodontol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/clr.13972","article-title":"Reconstructive surgical therapy of peri\u2010implantitis: a multicenter randomized controlled clinical trial","volume":"33","author":"Derks J","year":"2022","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00784-019-02943-8","article-title":"Non\u2010surgical therapeutic outcomes of peri\u2010implantitis: 12\u2010month results","volume":"24","author":"Nart J","year":"2020","journal-title":"Clin Oral Investig"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/jcpe.13564","article-title":"Adjunctive benefits of systemic metronidazole on non\u2010surgical treatment of peri\u2010implantitis. A randomized placebo\u2010controlled clinical trial","volume":"49","author":"Blanco C","year":"2022","journal-title":"J Clin Periodontol"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/jcpe.13993","article-title":"Treatment of peri\u2010implantitis with a flapless surgical access combined with implant surface decontamination and adjunctive systemic antibiotics: a retrospective case series study","volume":"51","author":"Carrillo de Albornoz A","year":"2024","journal-title":"J Clin Periodontol"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1600-0757.1994.tb00007.x","article-title":"Microbial aspects of implant dentistry","volume":"4","author":"Mombelli A","year":"1994","journal-title":"Periodontol 2000"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/jcpe.13129","article-title":"Interventions for peri\u2010implantitis and their effects on further bone loss: a retrospective analysis of a registry\u2010based cohort","volume":"46","author":"Karlsson K","year":"2019","journal-title":"J Clin Periodontol"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/clr.13914","article-title":"Non\u2010surgical peri\u2010implantitis treatment with or without systemic antibiotics: a randomized controlled clinical trial","volume":"33","author":"Polymeri A","year":"2022","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.11607\/jomi.2013.g5","article-title":"Consensus statements and clinical recommendations for prevention and management of biologic and technical implant complications","volume":"29","author":"Heitz\u2010Mayfield LJ","year":"2014","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/jcpe.13070","article-title":"Efficacy of reconstructive surgical therapy at peri\u2010implantitis\u2010related bone defects. A systematic review and meta\u2010analysis","volume":"46","author":"Tomasi C","year":"2019","journal-title":"J Clin Periodontol"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/jcpe.13121","article-title":"Regeneration of alveolar ridge defects. Consensus report of group 4 of the 15th European Workshop on Periodontology on Bone Regeneration","volume":"46","author":"Jepsen S","year":"2019","journal-title":"J Clin Periodontol"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/idj.12505","article-title":"Surgical treatment of peri\u2010implantitis\u2014Consensus report of working group 4","volume":"69","author":"Khoury F","year":"2019","journal-title":"Int Dent J"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s40729-021-00388-x","article-title":"Efficacy of alternative or adjunctive measures to conventional non\u2010surgical and surgical treatment of peri\u2010implant mucositis and peri\u2010implantitis: a systematic review and meta\u2010analysis","volume":"7","author":"Ramanauskaite A","year":"2021","journal-title":"Int J Implant Dent"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/clr.13881","article-title":"Erythritol air polishing in the surgical treatment of peri\u2010implantitis: a randomized controlled trial","volume":"33","author":"Hentenaar DFM","year":"2022","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pdpdt.2018.05.003","article-title":"Effect of antimicrobial photodynamic therapy in open flap debridement in the treatment of peri\u2010implantitis: a randomized controlled trial","volume":"23","author":"Albaker AM","year":"2018","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/jcpe.12583","article-title":"Effectiveness of enamel matrix derivative on the clinical and microbiological outcomes following surgical regenerative treatment of peri\u2010implantitis. 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I. revalence and severity","volume":"21","author":"Loe H","year":"1963","journal-title":"Acta Odontol Scand"},{"key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/0022034515610056","article-title":"Reconstruction of peri\u2010implant osseous defects: a multicenter randomized trial","volume":"95","author":"Jepsen K","year":"2016","journal-title":"J Dent Res"},{"key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1600-051X.2010.01540.x","article-title":"Impact of defect configuration on the clinical outcome following surgical regenerative therapy of peri\u2010implantitis","volume":"37","author":"Schwarz F","year":"2010","journal-title":"J Clin Periodontol"},{"key":"e_1_2_11_26_1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/clr.13818","article-title":"Reconstructive treatment of peri\u2010implantitis infrabony defects of various configurations: 5\u2010year survival and success","volume":"32","author":"Roccuzzo M","year":"2021","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_27_1","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/clr.13369","article-title":"Clinical and radiographic outcomes of a surgical reconstructive approach in the treatment of peri\u2010implantitis lesions: a 5\u2010year prospective case series","volume":"29","author":"La Monaca G","year":"2018","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_28_1","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1600-051X.2011.01742.x","article-title":"Surgical therapy of peri\u2010implantitis lesions by means of a bovine\u2010derived xenograft: comparative results of a prospective study on two different implant surfaces","volume":"38","author":"Roccuzzo M","year":"2011","journal-title":"J Clin Periodontol"},{"key":"e_1_2_11_29_1","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/jcpe.12308","article-title":"Surgical treatment of peri\u2010implantitis using a bone substitute with or without a resorbable membrane: a 5\u2010year follow\u2010up","volume":"41","author":"Roos\u2010Jansaker AM","year":"2014","journal-title":"J Clin Periodontol"},{"key":"e_1_2_11_30_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0022-3913(92)90248-9","article-title":"Effect of hygiene instrumentation on titanium abutments: a scanning electron microscopy study","volume":"67","author":"Homiak AW","year":"1992","journal-title":"J Prosthet Dent"},{"key":"e_1_2_11_31_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/clr.12773","article-title":"In vitro cleaning potential of three implant debridement methods. Simulation of the non\u2010surgical approach","volume":"28","author":"Ronay V","year":"2017","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_32_1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/clr.13441","article-title":"In vitro efficacy of three different implant surface decontamination methods in three different defect configurations","volume":"30","author":"Keim D","year":"2019","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_33_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-0501.2011.02186.x","article-title":"Effect of plastic\u2010covered ultrasonic scalers on titanium implant surfaces","volume":"23","author":"Mann M","year":"2012","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_34_1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/clr.13446","article-title":"The effect of five mechanical instrumentation protocols on implant surface topography and roughness: a scanning electron microscope and confocal laser scanning microscope analysis","volume":"30","author":"Cha JK","year":"2019","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_35_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/clr.12302","article-title":"Effects of titanium brush on machined and sand\u2010blasted\/acid\u2010etched titanium disc using confocal microscopy and contact profilometry","volume":"26","author":"Park JB","year":"2015","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_36_1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/clr.13991","article-title":"In vitro effect of different implant decontamination methods in three intraosseous defect configurations","volume":"33","author":"Luengo F","year":"2022","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_37_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/jre.12633","article-title":"Macrophage polarization in aseptic bone resorption around dental implants induced by Ti particles in a murine model","volume":"54","author":"Wang X","year":"2019","journal-title":"J Periodontal Res"},{"key":"e_1_2_11_38_1","doi-asserted-by":"crossref","DOI":"10.1038\/srep39612","article-title":"Scaling of titanium implants entrains inflammation\u2010induced osteolysis","volume":"7","author":"Eger M","year":"2017","journal-title":"Sci Rep"},{"key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/clr.14136","article-title":"Decontamination of biofilm\u2010contaminated implant surfaces: an in vitro evaluation","volume":"34","author":"Ichioka Y","year":"2023","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_40_1","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1111\/clr.13653","article-title":"Risk for recurrence of disease following surgical therapy of peri\u2010implantitis\u2010A prospective longitudinal study","volume":"31","author":"Carcuac O","year":"2020","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_41_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/jcpe.13775","article-title":"The efficacy of bone reconstructive therapies in the management of peri\u2010implantitis. A systematic review and meta\u2010analysis","author":"Donos N","year":"2023","journal-title":"J Clin Periodontol"},{"key":"e_1_2_11_42_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/clr.12910","article-title":"Supportive peri\u2010implant therapy following anti\u2010infective surgical peri\u2010implantitis treatment: 5\u2010year survival and success","volume":"29","author":"Heitz\u2010Mayfield LJA","year":"2018","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_43_1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1111\/clr.12941","article-title":"Long\u2010term outcomes of implants placed after vertical alveolar ridge augmentation in partially edentulous patients: a 10\u2010year prospective clinical study","volume":"28","author":"Roccuzzo M","year":"2017","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_44_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/clr.13256","article-title":"Regenerative surgical therapy for peri\u2010implantitis using deproteinized bovine bone mineral with 10% collagen, enamel matrix derivative and Doxycycline\u2010A prospective 3\u2010year cohort study","volume":"29","author":"Mercado F","year":"2018","journal-title":"Clin Oral Implants Res"},{"key":"e_1_2_11_45_1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/jcpe.12894","article-title":"Surgical treatment of peri\u2010implantitis using enamel matrix derivative, an RCT: 3\u2010 and 5\u2010year follow\u2010up","volume":"45","author":"Isehed C","year":"2018","journal-title":"J Clin Periodontol"},{"key":"e_1_2_11_46_1","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1902\/jop.2006.050360","article-title":"Comparison of interdental cleaning methods: a randomized controlled trial","volume":"77","author":"Jackson MA","year":"2006","journal-title":"J Periodontol"},{"key":"e_1_2_11_47_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/jcpe.13204","article-title":"Compliance with supportive periodontal\/peri\u2010implant therapy: a systematic review","volume":"47","author":"Amerio E","year":"2020","journal-title":"J Clin Periodontol"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.24-0673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T17:31:54Z","timestamp":1764696714000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/JPER.24-0673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/JPER.24-0673"],"URL":"https:\/\/doi.org\/10.1002\/jper.24-0673","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]},"assertion":[{"value":"2024-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}