{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:22:46Z","timestamp":1776252166846,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82101013"],"award-info":[{"award-number":["No. 82101013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["No. 2023YFC2506300"],"award-info":[{"award-number":["No. 2023YFC2506300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2022JQ\u2010959"],"award-info":[{"award-number":["2022JQ\u2010959"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study focused on whether the effectiveness of nonsurgical periodontal therapy (NSPT) on second molars (M2s) varies with the status of adjacent nonimpacted third molars (N\u2010M3s).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study, 776 regions from 268 patients were evaluated. Based on the adjacent N\u2010M3 status, quadrants with M2s were categorized into three groups: N\u2010M3 group (present N\u2010M3), A\u2010M3 group (absent M3), and R\u2010M3 group (removed N\u2010M3). The probing depth reduction (\u0394PD) and the percentage of reversed deep pockets (PD5+ [probing depth \u22655\u00a0mm] turned to PD5\u2212) after NSPT were analyzed among the three groups. The Wilcoxon nonparametric test was employed to compare the N\u2010M3 group with the A\u2010M3 group, with a mixed\u2010effect model utilized to adjust for confounding factors. Further, the R\u2010M3 group and the matched N\u2010M3 group were compared using the Wilcoxon nonparametric test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After isolating confounding factors (M2 baseline gingival recession, tooth mobility, sex, and follow\u2010up interval), the \u0394PD of M2s was significantly lower in the N\u2010M3 group (0.93\u00a0\u00b1\u00a01.25\u00a0mm) compared with the A\u2010M3 group (1.09\u00a0\u00b1\u00a01.30\u00a0mm,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001). Moreover, the percentage of reversed deep pockets in the N\u2010M3 group (35.56%) was lower than in the A\u2010M3 group (42.98%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001). Similarly, compared with the N\u2010M3 group, M2s in the R\u2010M3 group manifested better outcomes in terms of periodontal indices.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Retained N\u2010M3s may hamper the outcome of NSPT on adjacent M2s. Additionally, the removal of N\u2010M3 is associated with an enhanced response of M2s to NSPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary<\/jats:title>\n                    <jats:p>The second molar is crucial for chewing, but it is often lost due to periodontitis. Periodontal treatment for the second molar is not always effective, and many factors contribute to this. One factor that has gained attention is the impact of a nonimpacted third molar on the periodontal health of the adjacent second molar. In this study, we examined how the presence of a nonimpacted third molar affects the outcome of nonsurgical periodontal therapy for the second molar. We analyzed 776 second molars from 268 patients. The results showed that when the nonimpacted third molar was absent or removed during periodontal therapy, the second molar's condition improved more than when the nonimpacted third molar was present. The data indicated that even with nonsurgical periodontal treatment, the periodontitis of the second molar could not be effectively controlled if an adjacent nonimpacted third molar was present. Therefore, the negative impact of the nonimpacted third molar should be considered to prevent the loss of the second molar.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.24-0674","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T04:59:57Z","timestamp":1739249997000},"page":"1088-1098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Presence of nonimpacted third molars affects the response of neighboring teeth to nonsurgical periodontal therapy"],"prefix":"10.1002","volume":"96","author":[{"given":"Rui","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi International Joint Research Center for Oral Diseases Department of Periodontology School of Stomatology The Fourth Military Medical University Xi'an 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