{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:39:48Z","timestamp":1791088788483,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The present study aimed to investigate the expression of stromal cell\u2010derived factor\u20101 (SDF\u20101) after tooth extraction in rats and its regulatory effect on the expression of osteopontin (OPN) and vascular endothelial growth factor (VEGF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The first mandibular molar of the rats on the left was extracted, the histopathological changes of the extraction sockets were observed, and the SDF\u20101 protein and mRNA expression were measured at 0, 1, 4, 7, 10, and 14 days. Furthermore, we used AMD3100 to block SDF\u20101\/CXC chemokine receptor 4 (CXCR4) signaling, and the expression changes of SDF\u20101, OPN, and VEGF were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 1 day, the socket was filled with a blood clot. At 4 days, the granulation tissues were formed at the socket. At 7 days, the extraction socket was filled with mature fibrous connective tissue. At 10 days, a large amount of new trabecular bone was regenerated. At 14 days, the newly formed socket bone underwent remodeling. The expression level of SDF\u20101 began to increase on the first day after tooth extraction and then peaked at 4 days. Then, SDF\u20101 expression gradually declined and finally returned to the baseline level at 14 days. Moreover, the application of AMD3100 decreased the secretion of OPN and VEGF, both at protein and mRNA levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The expression of SDF\u20101 increased first and then decreased after tooth extraction. SDF\u20101 may play a regulatory role in the expression of OPN and VEGF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain language summary<\/jats:title>\n                    <jats:p>Tooth extraction is one of the most common operations that cause oral tissue defects and tooth loss. The healing of the tooth extraction wound affects the results of the later denture restoration and implant surgery. In this study, the expression of stromal cell\u2010derived factor\u20101 (SDF\u20101) increased first and then decreased after tooth extraction. It was found that after blocking the SDF\u20101 signaling pathway, the expression levels of osteopontin (OPN) and vascular endothelial growth factor (VEGF) decreased correspondingly. While OPN was a marker of bone maturation, VEGF could promote angiogenesis and thus tissue repair. In conclusion, SDF\u20101 may be involved in the process of tissue damage repair by regulating the expression of OPN and VEGF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.24-0785","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T15:10:11Z","timestamp":1751987411000},"page":"1391-1399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stromal cell\u2010derived factor\u20101 regulates expression of vascular endothelial growth factor and osteopontin after tooth extraction"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3370-9756","authenticated-orcid":false,"given":"Jingjing","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Jinan Stomatological Hospital  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Jinan Key Medical and Health Laboratory of Oral Diseases and Tissue Regeneration Jinan Key Laboratory of Oral Diseases and Tissue Regeneration Shandong Provincial Key Medical and Health Laboratory of Oral Diseases and Tissue Regeneration Shandong Provincial Key Medical and Health Discipline of Oral Medicine Department of Dental Implantology Jinan Stomatological Hospital  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[{"name":"Nursing Department Jinan Stomatological Hospital  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jinan Key Medical and Health Laboratory of Oral Diseases and Tissue Regeneration Jinan Key Laboratory of Oral Diseases and Tissue Regeneration Shandong Provincial Key Medical and Health Laboratory of Oral Diseases and Tissue Regeneration Shandong Provincial Key Medical and Health Discipline of Oral Medicine Department of Dental Implantology Jinan Stomatological Hospital  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1174-2664","authenticated-orcid":false,"given":"Jianli","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Jinan Stomatological Hospital  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Cui","sequence":"additional","affiliation":[{"name":"Jinan Key Medical and Health Laboratory of Oral Diseases and Tissue Regeneration Jinan Key Laboratory of Oral Diseases and Tissue Regeneration Shandong Provincial Key Medical and Health Laboratory of Oral Diseases and Tissue Regeneration Shandong Provincial Key Medical and Health Discipline of Oral Medicine Department of Dental Implantology Jinan Stomatological Hospital  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17113931"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.130689"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115618"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"3","article-title":"Effects of nicotine on the healing of extraction sockets in rats. 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