{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T17:41:56Z","timestamp":1764697316093,"version":"3.46.0"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T00:00:00Z","timestamp":1745107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401133"],"award-info":[{"award-number":["82401133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aims to assess the associations between exposures to thiocyanate and the risk of periodontitis among US adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross\u2010sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2009\u20132014. We categorized periodontitis according to the 2017 classification scheme. Restricted cubic spline analysis and weighted multivariable logistic regression were employed to examine the relationship between thiocyanate exposure and periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 3319 participants were included in our study. We observed a J\u2010shaped association between thiocyanate exposure and periodontitis, with an inflection point at 3.32. Before the inflection point, we noted a negative trend in the relationship between thiocyanate and periodontitis (odds ratio [OR]\u00a0=\u00a00.89, 95% CI:\u00a00.73\u20131.08), particularly among smokers (OR\u00a0=\u00a00.31, 95% CI:\u00a00.08\u20131.18). After the inflection point, we found a positive association (OR\u00a0=\u00a01.21, 95% CI:\u00a01.03\u20131.42), particularly among non\u2010obese individuals (OR\u00a0=\u00a01.42, 95% CI:\u00a01.16\u20131.75) and non\u2010hypertensive individuals (OR\u00a0=\u00a01.34, 95% CI:\u00a01.12\u20131.61).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A J\u2010shaped relationship exists between thiocyanate exposure and periodontitis, indicating its complex role, and further prospective trials are necessary to confirm these findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain language summary<\/jats:title>\n                    <jats:p>Thiocyanate, a compound prevalent in both the environment and dietary sources, can impact health through mechanisms that are either protective or detrimental. This study sought to investigate the specific relationship between thiocyanate exposure and periodontitis utilizing data from the National Health and Nutrition Examination Survey (NHANES). The findings reveal that both insufficient and excessive levels of thiocyanate exposure are linked to an increased risk of periodontitis, underscoring the critical importance of maintaining an optimal range of thiocyanate exposure for periodontal health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.24-0832","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:52:26Z","timestamp":1745196746000},"page":"1281-1290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["J\u2010shaped associations between thiocyanate and periodontitis: A cross\u2010sectional study from NHANES 2009\u20132014"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2885-4721","authenticated-orcid":false,"given":"Pengfei","family":"Liu","sequence":"first","affiliation":[{"name":"Ningbo Institute of Innovation for Combined Medicine and Engineering The Affiliated Lihuili Hospital of Ningbo University  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1518-686X","authenticated-orcid":false,"given":"Huan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University  Xi'an China"},{"name":"Department of Periodontology College of Stomatology Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1689-7257","authenticated-orcid":false,"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics Xiangya School of Public Health Central South University  Changsha 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