{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:40:38Z","timestamp":1792471238927,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Periodontitis requires long\u2010term management to prevent recurrence and tooth loss. While active periodontal therapy (APT) aims to reduce probing pocket depth (PPD) and improve clinical attachment level (CAL), strict supportive periodontal care (SPC) is essential for maintaining these clinical outcomes. This study systematically reviewed the long\u2010term benefits of APT interventions (test groups) compared to standard control interventions (control groups) in patients undergoing SPC as part of randomized controlled trials (RCTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of databases and journals identified RCTs with a minimum follow\u2010up of 10 years. Studies comparing APT interventions, such as regenerative techniques, to standard care in patients adhering to SPC were included. Primary outcomes assessed included tooth loss, and secondary outcomes included PPD reduction, CAL gain, and patient\u2010reported outcome measures (PROMs). Descriptive analyses were undertaken on all studies, and meta\u2010analyses were conducted to analyze the weighted mean differences (WMDs) for PPD, CAL, and tooth loss between test and control interventions when appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From an initial screening of 4582 articles, 9 were deemed suitable and included for descriptive analyses. Four publications of 3 studies were included in meta\u2010analyses comparing guided tissue regeneration (GTR) and open flap debridement (OFD) over a 10\u2010to 20\u2010year SPC follow\u2010ups. Regenerative techniques demonstrated significant CAL gains at 1\u2010year follow\u2010up compared to control groups. At 10 to 20 years, PPD and CAL outcomes were comparable between groups. Tooth loss was minimal across all groups. Variability in SPC protocols and operator experience may have influenced outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long\u2010term periodontal stability does not appear to be affected by the choice of initial intervention in patients who adhere to a rigorous SPC program. While regenerative techniques offer short\u2010term advantages, their long\u2010term benefits may reduce in comparison to non\u2010regenerative methods under SPC. Future research should focus on standardized SPC protocols and cost\u2010effectiveness to optimize periodontal care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary<\/jats:title>\n                    <jats:p>Periodontitis is a chronic immune\u2010inflammatory condition that can lead to increased risk of tooth loss if not managed. Treatment such as non\u2010surgical periodontal therapy (NSPT), adjunctive therapies, or various surgeries can improve periodontal health. This systematic review examined randomized controlled trials (RCTs) where patients received different periodontal treatments and were then followed up for \u226510 years while attending maintenance visits. Periodontal surrogate and true endpoints were compared between the test and control groups. The findings suggest that long\u2010term outcomes were similar between groups, provided patients remained in consistent maintenance care. This highlights that the key to long\u2010term success is not necessarily which active treatment is used, but possibly the adherence to structured maintenance. These results allow clinicians and researchers to understand the types of treatments that may have lasting benefits and reinforces the importance of long\u2010term care in preventing disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.70027","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T13:40:47Z","timestamp":1763473247000},"page":"450-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term clinical benefits of periodontal interventions in strict supportive periodontal care: A systematic review"],"prefix":"10.1002","volume":"97","author":[{"given":"Varkha","family":"Rattu","sequence":"first","affiliation":[{"name":"Periodontology Unit Centre for Host\u2010Microbiome Interactions Dental Institute, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tishani","family":"Patel","sequence":"additional","affiliation":[{"name":"Periodontology Unit Centre for Host\u2010Microbiome Interactions Dental Institute, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Loke","sequence":"additional","affiliation":[{"name":"Periodontology Unit Centre for Host\u2010Microbiome Interactions Dental Institute, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari","family":"Petsos","sequence":"additional","affiliation":[{"name":"Department of Periodontology Goethe University Frankfurt\/Main Centre of Dentistry and Oral Medicine (Carolinum)  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Nibali","sequence":"additional","affiliation":[{"name":"Periodontology Unit Centre for Host\u2010Microbiome Interactions Dental Institute, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13639"},{"issue":"2","key":"e_1_2_11_4_1","first-page":"41","article-title":"Proposal of a clinical endpoint for periodontal trials: the treat\u2010to\u2010target approach","volume":"22","author":"Feres M","year":"2020","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13835"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.1986.tb01482.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1983.tb02182.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1987.tb02249.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u2010051x.2001.028005446.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2009.01474.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13110"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2008.01295.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12638"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13627"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2007.01160.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120238"},{"issue":"6","key":"e_1_2_11_19_1","first-page":"641","article-title":"Comparison of modified widman and coronally advanced flap surgery combined with Co2 laser root irradiation in periodontal therapy: a 15\u2010year follow\u2010up","volume":"31","author":"Crespi R","year":"2011","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u2010051x.2001.028010910.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1179\/1465313314Y.0000000111"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1532\u20103382(12)70021\u20100"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13259"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13246"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13237"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13289"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1981.tb02039.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2004.00563.x"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jper.70027","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jper.70027","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jper.70027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:49:40Z","timestamp":1777697380000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/jper.70027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/jper.70027"],"URL":"https:\/\/doi.org\/10.1002\/jper.70027","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]},"assertion":[{"value":"2025-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}