{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:43:41Z","timestamp":1789152221923,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>An association between periodontal disease and diabetes exists, although the mechanisms associated with treatment response and glycemic control are not fully elucidated. The goals of this study were to evaluate the clinical response, local (gingival crevicular fluid \u2013 GCF) and systemic (serum) inflammatory and metabolic profile following periodontal treatment of type II diabetic subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010two type II diabetic subjects with hemoglobin A1C (HbA1c)\u00a0&gt;\u00a06.5 and periodontitis were evaluated following non\u2010surgical periodontal treatment. Periodontal parameters (e.g., pocket depth \u2013 PD, clinical attachment level \u2013 CAL, and bleeding on probing \u2013 BoP), HbA1c, local and systemic inflammatory mediators were evaluated at baseline, 3, 6, and 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All periodontal parameters were reduced post\u2010treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Although HbA1c levels were not reduced post\u2010treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.515), they were positively associated with baseline PD\u00a0&gt;\u00a04\u00a0mm and BoP as well as with PD\/CAL and PD\u00a0&gt;\u00a04\u00a0mm reductions. Both local and systemic inflammatory profiles were modulated post\u2010treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), with local reductions of INF\u2010\u03b3, IL\u201010, IL\u201012p40, MIP\u20101\u03b1, and GM\u2010CSF at 3 months (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), and systemic Eotaxin at 12 months. Other systemic markers increased post\u2010treatment. HbA1c was associated with local IL\u20101\u03b2 and systemic Eotaxin reductions (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Uncontrolled diabetic subjects showed a positive clinical response and differentiated local and systemic profile post\u2010treatment, where local markers were reduced in the short\u2010term and several systemic markers increased. Although HbA1c was not reduced post\u2010treatment, it was associated with clinical and some inflammatory response. ClinicalTrials.gov ID NCT01881074.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.70035","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T17:47:46Z","timestamp":1768844866000},"page":"960-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of periodontal therapy on clinical and inflammatory parameters in type II diabetics"],"prefix":"10.1002","volume":"97","author":[{"given":"Julie","family":"Tokatlian","sequence":"first","affiliation":[{"name":"Department of Oral Health Practice Periodontology Division College of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohanad","family":"Al\u2010Sabbagh","sequence":"additional","affiliation":[{"name":"Department of Oral Health Practice Periodontology Division College of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolphus R.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Department of Oral Health Practice Periodontology Division College of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine College of Medicine, Division of Primary Care University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Oelisoa","family":"Andriankaja","sequence":"additional","affiliation":[{"name":"Center for Oral Health Research College of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuben","family":"Adatorwovor","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Public Health University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela Maria Viana","family":"Miguel","sequence":"additional","affiliation":[{"name":"Center for Oral Health Research College of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Macchion","family":"Shaddox","sequence":"additional","affiliation":[{"name":"Department of Oral Health Practice Periodontology Division College of Dentistry University of Kentucky  Lexington Kentucky USA"},{"name":"Center for Oral Health Research College of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71908-9"},{"key":"e_1_2_10_3_1","unstructured":"National Center for Chronic Disease Prevention and Health Promotion; Diabetes. 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