{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T13:55:36Z","timestamp":1786456536627,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fibroblast growth factor\u20102 (FGF\u20102) is a novel agent utilized in periodontal regeneration therapy. However, its clinical efficacy compared with autologous bone graft (ABG), a long\u2010established treatment, remains unclear. This study aimed to compare the clinical outcomes of FGF\u20102 and ABG and to assess the impact of patient background factors on outcomes when using FGF\u20102.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected the subjects from January 2013 to September 2023. Clinical outcomes included the vertical bone defect improvement rate (VBDIR) and the probing pocket depth improvement (PPDI). Clinical outcomes between the two groups were compared using analysis of covariance (ANCOVA), adjusting for age, sex, smoking history, and hypertension. Additionally, a multilevel linear analysis was performed to assess factors influencing outcomes in FGF\u20102.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 180 sites from 141 patients (FGF\u20102: 150 sites; ABG: 30 sites) were evaluated. Both VBDIR and PPDI significantly improved postoperatively in both groups. There were no significant differences in clinical outcomes between FGF\u20102 and ABG. In FGF\u20102, smoking history was positively associated, while the preoperative bone defect angle (BDA) was negatively associated with clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FGF\u20102 might exhibit clinical outcomes comparable to those of ABG, suggesting it is a clinically viable alternative for vertical bone defects. When using FGF\u20102, patient\u2010specific factors such as smoking history and preoperative BDA should be considered carefully.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>The name in the trial registry<\/jats:title>\n                    <jats:p>A survey of clinical practice and evaluation of treatment outcomes of periodontal regenerative therapy using REGROTH at Okayama University Hospital<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain language summary<\/jats:title>\n                    <jats:p>This retrospective study compared the clinical outcomes of fibroblast growth factor\u20102 (FGF\u20102), a novel therapeutic agent, with autologous bone graft (ABG), a long\u2010established treatment. A total of 180 sites from 141 patients (150 FGF\u20102 sites, 30 ABG sites) were evaluated based on the vertical bone defect improvement rate (VBDIR) and the probing pocket depth improvement (PPDI). Using analysis of covariance (ANCOVA), adjusted for patient background factors such as age, sex, smoking history, and hypertension, no significant differences in clinical outcomes were observed between the two treatment groups. Further multilevel linear analysis focusing on the FGF\u20102 group revealed that smoking history was positively associated, while preoperative bone defect angle (BDA) was negatively associated with clinical outcomes. These findings suggest that FGF\u20102 may offer clinical benefits comparable to ABG in treating vertical bone defects while having the added advantage of being less invasive. However, when using FGF\u20102, dentists should consider individual patient factors such as smoking habits and defect morphology, as these may influence treatment outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.70060","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T17:49:43Z","timestamp":1768844983000},"page":"1431-1441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A retrospective cohort study comparing periodontal regeneration using fibroblast growth factor\u20102 versus autologous bone graft"],"prefix":"10.1002","volume":"97","author":[{"given":"Toshiki","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Pathophysiology\u2013Periodontal Science Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\u2013Periodontal Science Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Ito\u2010Shinoda","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\u2013Periodontal Science Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\u2013Periodontal Science Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\u2013Periodontal Science Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuki","family":"Nonomura","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\u2013Periodontal Science Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Ideguchi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\u2013Periodontal Science Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Endodontics, Division of Dentistry Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazu","family":"Takeuchi\u2010Hatanaka","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Endodontics, Division of Dentistry Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Omori","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\u2013Periodontal Science Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"The Center for Graduate Medical Education (Dental Division) Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Takashiba","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\u2013Periodontal Science Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1976.47.5.256"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"37","article-title":"Initiator paper. 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