{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:47:44Z","timestamp":1792032464873,"version":"4.4.0"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) are analogs of the endogenous incretin hormone GLP\u20101 and are increasingly used in the treatment of diabetes and obesity. Beyond glycemic control and weight loss, they have demonstrated anti\u2010inflammatory, antioxidative, and immunomodulatory properties. Given the inflammatory nature of periodontitis and its bidirectional relationship with diabetes mellitus, interest is growing in exploring the potential therapeutic benefits of GLP\u20101 RAs in periodontal diseases. This scoping review aims to search the existing literature on the effects of GLP\u20101 RAs on periodontitis, focusing on underlying mechanisms and emerging clinical implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following PRISMA guidelines for scoping reviews, a comprehensive search was conducted in Medline\/PubMed and Embase to identify preclinical and clinical studies in English evaluating the effects of GLP\u20101 RAs on periodontal tissues. Data were synthesized thematically to highlight key findings and gaps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Evidence from mechanistic and preclinical studies supports a biologically plausible link between GLP\u20101 RAs and pathways central to periodontal inflammation and host response. Human studies remain limited and observational but consistently report associations between periodontitis and altered incretin hormone profiles, including reduced endogenous GLP\u20101 levels and increases following periodontal treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This scoping review identifies growing mechanistic and preclinical evidence suggesting potential interactions between GLP\u20101 RAs and periodontal inflammatory pathways. Although current human evidence is indirect and insufficient to establish therapeutic benefit, these early signals highlight an important opportunity for future research. Well\u2010designed clinical trials with periodontal endpoints are needed to clarify whether GLP\u20101 RAs may provide adjunctive value in periodontal care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain language summary<\/jats:title>\n                    <jats:p>GLP\u20101 receptor agonists are medications commonly used to manage diabetes and obesity. In addition to their metabolic effects, laboratory and animal studies suggest that these drugs may influence biological processes also involved in gum disease, such as inflammation, immune response, and bone metabolism. This scoping review examined all available scientific studies on the relationship between GLP\u20101 receptor agonists and periodontal disease. Most of the existing evidence comes from mechanistic and preclinical research showing that these medications can reduce inflammation and support tissue repair in experimental models. Human studies are still very limited and have focused mainly on metabolic markers rather than on direct measures of gum health. So far, no clinical trial has tested whether GLP\u20101 medications can improve periodontal outcomes. Although no conclusions can be made for clinical dental practice today, the findings highlight an emerging and promising area of research. Well\u2010designed clinical studies are needed to determine whether GLP\u20101 receptor agonists could eventually play a role in periodontal treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.70092","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:43:57Z","timestamp":1771505037000},"page":"1243-1256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["GLP\u20101 receptor agonists: Bridging diabetes, obesity, and periodontitis\u2014A scoping review of emerging evidence"],"prefix":"10.1002","volume":"97","author":[{"given":"Angeliki","family":"Polymeri","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Infection and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Feres","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William V.","family":"Giannobile","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno G.","family":"Loos","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"},{"name":"Department of Periodontology, ACTA \u2013 Academic Centre for Dentistry Amsterdam University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12911"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2012.638282"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.054"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.001"},{"key":"e_1_2_12_6_1","volume-title":"StatPearls","author":"Wafa L","year":"2023"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci24\u20100003"},{"key":"e_1_2_12_8_1","unstructured":"U.S. Food and Drug Administration.FDA Approves New Drug Treatment for Chronic Weight Management First Since2014. 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