{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:09:41Z","timestamp":1789168181322,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This randomized controlled trial aims to evaluate alveolar ridge preservation (ARP) with or without a biologically active amnion\u2013chorion membrane (BACM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty patients requiring tooth extraction in the esthetic zone were randomly assigned to 2 groups. Both groups underwent tooth extraction and collagenated bovine bone grafting, while the test sites received an additional BACM. Cone\u2010beam computed tomography (CBCT) and intraoral scans (IOS) were performed before extraction and at 4 months post\u2010extraction. Patient\u2010reported outcomes (PROs) were assessed. The primary endpoint was the change in vertical and horizontal hard and soft tissue dimensions as measured by CBCT and clinically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All patients completed implant placement. CBCT measurements at 2\u00a0mm demonstrated that control and test groups exhibited reductions in horizontal ridge width with median decreases of 1.19\u00a0mm and 2.41\u00a0mm, respectively, with no significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.126). For vertical height changes, the control and test groups experienced mean reductions of 0.99\u00a0\u00b1\u00a01.08\u00a0mm and 1.33\u00a0\u00b1\u00a00.73\u00a0mm, respectively, with no significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.250). IOS analyses showed that mean soft tissue thickness at the alveolar crest was 2.67\u00a0\u00b1\u00a00.699\u00a0mm (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.370) in the control versus 2.13\u00a0\u00b1\u00a00.807\u00a0mm (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.846) in the test group, with no significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.325).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The addition of a BACM did not improve the mean horizontal or vertical bone dimentional changes or have a measurable effect on the soft tissue outcome during ARP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.70094","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:54:40Z","timestamp":1772981680000},"page":"1871-1884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of bioactive membrane in alveolar ridge preservation: A double\u2010blind randomized clinical trial"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0695-6273","authenticated-orcid":false,"given":"Magdalena","family":"Orlowska","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5067-7317","authenticated-orcid":false,"given":"Muhammad H. 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